RAGE Expression and ROS Generation in Neurons: Differentiation versus Damage

Figure 1

Schematic representation of full-length RAGE and its variants. fl-RAGE is composed of a V-type domain, two C-type domains, a transmembrane domain, and an intracellular tail. The N-truncated form is lacking the N-terminal V-type domain. The soluble form of RAGE is lacking the C-terminal domain but containing all of the immunoglobulin domains. Soluble RAGE may derive from alternative splicing of RAGE mRNA (endogenous secretory esRAGE) or from fl-RAGE proteolytic cleavage from the cell surface (cleaved cRAGE) [13].