Effect of Intraperitoneal Etanercept on Oxidative Stress in Rats with Peritonitis
Table 2
Comparison of serum and tissue oxidant and antioxidant parameters.
Parameters
Group 1
Group 2
Group 3
Group 4
()
()
()
()
Serum
MDA (mmol/mL)
0.73 ± 0.17
1.67 ± 0.32
1.28 ± 0.21
0.90 ± 0.26
TOS (mol/L)
33.59 ± 11.23
80.30 ± 11.26
52.73 ± 12.48
39.07 ± 7.07
NO (M/L)
4.85 ± 0.39
5.80 ± 0.46
5.41 ± 0.32
4.90 ± 0.32
TNF- (pg/mL)
2.72 ± 1.45
18.50 ± 10.01
9.01 ± 2.06
5.77 ± 2.34
TAC (mmol/L)
1.32 ± 0.10
0.87 ± 0.30
1.18 ± 0.10
1.56 ± 0.11
PON (U/L)
197.03 ± 37.63
124.61 ± 15.81
145.67 ± 7.75
157.70 ± 10.25
Peritoneal tissue
MDA (mmol/mL)
0.12 ± 0.25
1.31 ± 0.41
0.59 ± 0.35
0.12 ± 0.07
TOS (mol/L)
7.16 ± 3.53
45.90 ± 26.57
14.18 ± 4.58
8.77 ± 4.11
NO (M/L)
3.95 ± 0.87
6.65 ± 1.36
6.00 ± 0.52
5.29 ± 0.22
TNF- (pg/mL)
116.39 ± 42.36
487.21 ± 238.44
265.22 ± 52.74
136.83 ± 24.26
TAC (mmol/L)
0.80 ± 0.11
0.34 ± 0.08
0.47 ± 0.064
0.66 ± 0.14
PON (U/L)
12.74 ± 3.32
1.83 ± 2.54
4.82 ± 1.37
8.34 ± 1.14
MDA: malondialdehyde, NO: nitric oxide, TNF-α: tumor necrosis factor alpha, TAC: total antioxidant capacity, TOS: total oxidant stress, and PON: paraoxonase. as compared to group 1, as compared to group 2, as compared to group 3, as compared to group 1, as compared to group 2, and as compared to group 3.
