Antioxidant and Hypolipidemic Activity of the Hydroethanolic Extract of Curatella americana L. Leaves
Table 2
Serum lipid profile and hepatic and renal parameters of normolipidemic and hyperlipidemic Wistar rats induced by high-fructose diet (66%) treated with water (control), simvastatin (20 mg⋅kg−1 of body weight, simvastatin), ciprofibrate (2 mg⋅kg−1 of body weight, ciprofibrate), and hydroethanolic extract of C. americana L. leaves (ExC) (200 mg⋅kg−1 of body weight, ExC).
Parameters
Normolipidemic
Hyperlipidemic
Control
Simvastatin
Ciprofibrate
ExC
Total cholesterol (mg⋅dL−1)
80.0 ± 2.0
118.3 ± 13.0
91.3 ± 5.2
86.4 ± 4.3
77.9 ± 4.1
HDL-cholesterol (mg⋅dL−1)
45.0 ± 2.4
58.0 ± 4.4
54.0 ± 3.1
47.0 ± 2.4
46.0 ± 2.3
Triglycerides (mg⋅dL−1)
138.3 ± 23.0
225.0 ± 33.0
119.0 ± 7.0
155.0 ± 14.0
136.9 ± 7.5
AST (U⋅L−1)
174.0 ± 6.5
178.0 ± 14.5
220.0 ± 20.1
209.0 ± 9.4
191.8 ± 12.3
ALT (U⋅L−1)
53.2 ± 3.3
65.4 ± 7.0
64.9 ± 5.6
65.0 ± 4.0
64.3 ± 9.3
Urea (U⋅L−1)
23.0 ± 2.0
30.0 ± 3.1
21.0 ± 1.4
26.0 ± 3.7
24.0 ± 3.8
Creatinine (U⋅L−1)
0.28 ± 0.02
0.34 ± 0.03
0.32 ± 0.02
0.30 ± 0.02
0.27 ± 0.02
Mean values followed by different superscript letters indicate significant difference (P < 0.05).
