Functionalized Fullerene Increases NF-<i>κ</i>B Activity and Blocks Genotoxic Effect of Oxidative Stress in Serum-Starving Human Embryo Lung Diploid Fibroblasts

<div>F-828 shifts the content of phosphorylated form of H2AX histone in serum-starving HELFs. (a) (Fluorescence microscopy, ×40): cells were processed for immunofluorescence staining with anti-<i>γ</i>H2AX antibody and PI. Detected types of nuclei are denoted with digits: 1: nucleus with multiple dsDNA breaks; 2: nucleus with a few dsDNA breaks; 3: nucleus without gamma-foci. (b) (FCA): (1): the FL1-<i>γ</i>H2AX versus SSC plots. Gates R1, R2, and R3 encircle the fractions of HELFs with various content of <i>γ</i>H2AX. (2): changes of the proportions of three cell fractions in the HELF cell pool depending on the F-828 concentration.</div>

Oxidative Medicine and Cellular Longevity

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Figure 9

Figure 9: Functionalized Fullerene Increases NF-<i>κ</i>B Activity and Blocks Genotoxic Effect of Oxidative Stress in Serum-Starving Human Embryo Lung Diploid Fibroblasts 

Figure 9 | Functionalized Fullerene Increases NF-κB Activity and Blocks Genotoxic Effect of Oxidative Stress in Serum-Starving Human Embryo Lung Diploid Fibroblasts 