Markers of Oxidative Stress and Inflammation in Ascites and Plasma in Patients with Platinum-Sensitive, Platinum-Resistant, and Platinum-Refractory Epithelial Ovarian Cancer

Table 3

Oxidative and inflammatory state in ovarian cancer. A significant increase of the 8-IP marker in ascites fluid versus baseline plasma levels can be observed. Also, an important leakage of antioxidants (TAC) in ascites fluid compared to plasma levels of healthy controls and the baseline TAC evaluations. A significant increase of IL-6 in ascites fluid versus baseline plasma levels was found. The TNF-α was significantly diminished in ascites and elevated in baseline evaluations.

	Healthy control plasma	Ascites	^Ŧp = HC versus ascites	^¥p = HC versus baseline	Plasma		^¤p = baseline–final	^§p = plasma baseline versus ascites
					Basal	Final
Oxidants
8-IP pg/mL	12.35 ± 1.47	117.40 ± 62.70	0.01	0.48	15.13 ± 1.50	16.90 ± 1.60	0.14	0.002
LPO μM	2.68 ± 0.28	12.60 ± 5.80	0.50	0.56	2.70 ± 0.30	2.60 ± 0.30	0.26	0.11
Antioxidant
TAC mM trolox	429.42 ± 61.50	909.30 ± 78.60	0.001	0.03	294.40 ± 24.10	337.80 ± 17.10	0.19	<0.001
Proinflammatory cytokines
IL-6 pg/mL	448.34 ± 28.00	1342.30 ± 188.90	0.007	0.42	703.50 ± 162.40	855.90 ± 327.90	0.31	0.003
TNF-α pg/mL	160.30 ± 12.70	120.80 ± 30.90	0.06	0.36	190.40 ± 17.90	164.40 ± 34.22	0.18	0.001

TAC: total antioxidant capacity. ^ŦHealthy control (HC) versus ascites Mann–Whitney U test. ^¥HC versus baseline plasma Mann–Whitney U test. ^¤Baseline–final Wilcoxon test. ^§Baseline plasma versus ascites Mann–Whitney U test.