Markers of Oxidative Stress and Inflammation in Ascites and Plasma in Patients with Platinum-Sensitive, Platinum-Resistant, and Platinum-Refractory Epithelial Ovarian Cancer

Table 4

Oxidative and inflammatory status in plasma due to ovarian cancer in all patients. Noteworthy are the levels in healthy controls versus the study groups and the significant difference depending on the response to platinum in relation to total antioxidant capacity.

	Healthy control	Platinum-sensitive	Platinum-resistant	Platinum-refractory	(K-W)	(K-W)
Antioxidant
TAP mM trolox	429.42 ± 61.50	283.80 ± 33.30	179.10 ± 18.40	393.40 ± 31.60	0.007	0.015
Oxidants
8-IP pg/mL	12.35 ± 1.47	13.60 ± 2.14	10.40 ± 1.70	19.20 ± 2.80	0.26	0.22
LPO μM	2.68 ± 0.28	2.70 ± 0.29	1.78 ± 0.25	3.20 ± 0.78	0.38	0.32
Proinflammatory cytokines
IL-6 pg/mL	448.34 ± 28.00	936.40 ± 284.60	834.20 ± 31.00	369.60 ± 105.00	0.44	0.33
TNF-α pg/mL	160.30 ± 12.70	201.10 ± 30.00	249.80 ± 28.50	145.40 ± 22.30	0.27	0.21

Comparison between the study groups with the healthy control. Comparison between the study groups. TAC: total antioxidant capacity; LPO: lipoperoxides; 8-IP: isoprostanes; IL-6: interleukin-6; TNF-α: tumor necrosis factor alpha; K-W: Kruskall Wallis test.