Preclinical Antileukemia Activity of Tramesan: A Newly Identified Bioactive Fungal Metabolite

Figure 5

TR induces a dose- and time-dependent apoptosis in primary cells from AML. AML primary cells were exposed to the indicated concentrations of TR. Apoptosis induction was then evaluated by the AO technique. Percentages of sub-G0/1 cells are shown for the individual sample after 72–120 h (a) and 144–168 h (b) exposure to scalar concentrations of TR. A representative experiment is shown (c).

(a)

(b)

(c)