4-Hydroxychalcone Induces Cell Death via Oxidative Stress in <i>MYCN</i>-Amplified Human Neuroblastoma Cells

<div>4HC-induced NB cell death is prevented by scavenging of mitochondrial superoxide. (a, b) Cell viability measured by MTT assay and (c) representative photomicrographs of (a, c) SK-N-BE (2) and (b, c) IMR-32 cells pretreated with mito-TEMPO (MT) before being cultured with or without 25 <i>μ</i>M of 4HC or SK-N-BE (2) and 10 <i>μ</i>M 4HC for IMR-32 for 24 h. <span class="nowrap"><svg height="12.7373pt" id="M50" style="vertical-align:-3.429399pt" version="1.1" viewbox="-0.0498162 -9.3079 93.5425 12.7373" width="93.5425pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M409 504C401 567 396 607 392 642C354 654 312 665 266 665C137 665 60 583 60 487C60 374 161 325 225 290C300 250 355 215 355 141C355 68 311 21 235 21C131 21 86 122 71 183L41 176C48 128 61 42 68 21C78 16 93 8 118 0C142 -7 175 -15 216 -15C349 -15 438 69 438 174C438 287 344 333 265 374C186 414 138 449 138 522C138 576 172 631 249 631C336 631 363 562 380 499L409 504Z"></path></g><g transform="matrix(.013,0,0,-0.013,6.345,0)"><path 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Oxidative Medicine and Cellular Longevity

fig6

Figure 6

Figure 6: 4-Hydroxychalcone Induces Cell Death via Oxidative Stress in <i>MYCN</i>-Amplified Human Neuroblastoma Cells 

Oxidative Medicine and Cellular Longevity

4-Hydroxychalcone Induces Cell Death via Oxidative Stress in MYCN-Amplified Human Neuroblastoma Cells

Figure 6