Oxidative Medicine and Cellular Longevity

Research Article

The Protective Role of Adiponectin for Lipoproteins in End-Stage Renal Disease Patients: Relationship with Diabetes and Body Mass Index

Table 2

Body mass index (BMI), lipid profile, paraoxonase (PON) 1 activity, C-reactive protein (CRP), and fractions and subfractions of lipoproteins, for end-stage renal disease (ESRD) patients on chronic dialysis, according to the more prevalent comorbidities, diabetes mellitus (DM) and hypertension (HT).


	noDM/HT ()	HT ()	DM ()	DM+HT ()

BMI (kg/m²)			28.0^aa ± 4.7	27.4^aaa ± 4.0^b
Biochemical data
TC (mg/dl)				149^aa ± 38^b,
HDLc (mg/dl)	50.6 (43.8–59.6)	46.1 (40.0–61.9)	39.7^aa, (34.8–47.8)^b	43.0^aa (36.9–53.8)
LDLc (mg/dl)	88 (68–107)	77 (65–112)	82 (64–105)	^a72 (57–91)
TG (mg/dl)	121.0 (96–165.5)	115.0 (85.0–141.5)	189.0^a, (116.0–258.0)^bb	141.0^a, (98.9–195.0)^b
TC/HDLc	3.37 (2.71–4.04)	3.40 (2.44–4.23)	3.38 (3.00–4.98)	3.15 (2.74–4.04)
LDLc/HDLc	1.80 (1.28–2.27)	1.83 (1.06–2.41)	1.79 (1.65–3.10)	1.67 (1.29–2.16)
PON1 (nmol of p-nitrophenol/ml/min)	410 (368–476)	384 (350–472)	431 (355–480)	398 (362–466)
PON1/HDLc	8.74 (6.52–10.13)	8.45 (6.32–10.92)	10.38^a, (9.00–13.86)^b	9.73^a, (7.41–11.74)
CRP (mg/dl)	0.43 (0.18–0.74)	0.46 (0.19–0.99)	0.53 (0.24–0.93)	0.24^a (0.11–0.48)^b
Lipoprotein fractions/subfractions
VLDL (%)
MID-C (%)
MID-B (%)	7.8 (6.8–8.7)	7.2 (6.1–8.3)	7.3 (6.4–9.4)	8.3 (6.8 -10.1)^b
MID-A (%)	6.5 (5.1–7.6)	6.8 (5.9–8.2)	5.7 (4.6–8.8)	7.4 (5.6–8.9)^a
LDL 1 (%)	12.8 (10.7–15.0)	13.5 (10.6–15.9)	12.4 (9.8–14.0)	13.3 (11.3–15.9)
LDL 2 (%)	8.3 (6.2–11.6)	8.2 (4.4–10.5)	7.8 (6.2–11.2)	8.0 (5.1–9.9)
LDL 3-7 (%)	0.7 (0.0–1.6)	0.4 (0.0–1.7)	0.9 (0.0–4.6)	0.8 (0.0–1.6)
HDL (%)	27.6 (24.3–30.8)	28.4 (22.6–33.8)	25.3^a (22.2–27.0)	24.8^aa (21.9–29.4)^b,
LDL size	270 (268–272)	270 (268–273)	271 (264–272)	270 (268–272)
HDL subfractions
Large HDL (%)	40.6 (29.4–46.2)	39.6 (29.3–48.7)	35.0^a, (21.1–39.6)^b	33.2^aa, (26.0–41.6)^b,
Intermediate HDL (%)	45.0 (41.2-48.6)	43.7 (39.4–48.9)	50.0^a (41.9–51.0)^b	46.4 (43.1–50.4)
Small HDL (%)	15.0 (11.1–21.6)	16.4 (12.0–21.3)	21.9 (12.8–21.7)	19.1^a, (13.9–24.0)

TC: total cholesterol; HDLc: high-density lipoprotein cholesterol; LDLc: low-density lipoprotein cholesterol; TG: triglycerides; VLDL: very-low-density lipoprotein; MID: midbands (these comprise intermediate-density lipoprotein (IDL)); LDL 3–7 corresponds to small LDL subfractions. Values are presented as median (interquartile range) or as deviation (SD); ^a, ^aa, and ^aaa vs. ESRD patients without DM or HT (noDM/HT); ^b, ^bb, and ^bbb vs. ESRD patients with HT; loss of significance after statistical adjustment for BMI.