LncRNA LEGLTBC Functions as a ceRNA to Antagonize the Effects of miR-34a on the Downregulation of SIRT1 in Glucolipotoxicity-Induced INS-1 Beta Cell Oxidative Stress and Apoptosis

<div>Profile of RNA-Seq data for lncRNAs. (a) Hierarchical clustering shows distinguished lncRNA expression profiling between control (Con) and HG/PA-treated INS-1 cells (3 replicates). Red, high expression; blue, low expression. (b) Scatter plot displays the variation of lncRNAs between Con and HG/PA-treated INS-1 cells. Red, upregulation; blue, downregulation. (c) The results reveal that the ten lncRNAs were downregulated or upregulated in HG/PA-treated INS-1 cells relative to control INS-1 cells. The qRT-PCR results were correlated well with the RNA-Seq data. (d) The results show the expression of these lncRNAs in HG/PA-treated rat islets compared to control islets. Data are the mean of ±SD of 5 independent experiments.</div>

Oxidative Medicine and Cellular Longevity

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Figure 1: LncRNA LEGLTBC Functions as a ceRNA to Antagonize the Effects of miR-34a on the Downregulation of SIRT1 in Glucolipotoxicity-Induced INS-1 Beta Cell Oxidative Stress and Apoptosis 

Figure 1 | LncRNA LEGLTBC Functions as a ceRNA to Antagonize the Effects of miR-34a on the Downregulation of SIRT1 in Glucolipotoxicity-Induced INS-1 Beta Cell Oxidative Stress and Apoptosis 