LncRNA LEGLTBC Functions as a ceRNA to Antagonize the Effects of miR-34a on the Downregulation of SIRT1 in Glucolipotoxicity-Induced INS-1 Beta Cell Oxidative Stress and Apoptosis

<div>Effects of LEGLTBC silencing on rat pancreatic islets. (a) Downregulation of LEGLTBC using siRNA for 48 h and the expression of LEGLTBC in HG/PA-treated rat islets assessed by qRT-PCR analysis. (b) The expression of miR-34a in HG/PA-treated rat islets was assessed by qRT-PCR analysis. Rat pancreatic islets transfected with si-NC or si-LEGLTBC were treated with HG/PA, followed by the detection of SIRT1 and cleaved caspase 3 expression (c, d, and e) and ROS production (f). 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Oxidative Medicine and Cellular Longevity

fig7

Figure 7

Figure 7: LncRNA LEGLTBC Functions as a ceRNA to Antagonize the Effects of miR-34a on the Downregulation of SIRT1 in Glucolipotoxicity-Induced INS-1 Beta Cell Oxidative Stress and Apoptosis 

Figure 7 | LncRNA LEGLTBC Functions as a ceRNA to Antagonize the Effects of miR-34a on the Downregulation of SIRT1 in Glucolipotoxicity-Induced INS-1 Beta Cell Oxidative Stress and Apoptosis 