Preterm infants (31 weeks gestational age, both sexes)/22 infants with PVL 22 healthy
Association between OS and neonatal cystic periventricular leukomalacia (PVL)
ROM/BAP was higher in early cystic PVL than in late cystic PVL or controls. Postnatal duration until cyst identification displayed a negative correlation with ROM/BAP
Neonates experiencing more OS at birth show earlier onset of cystic PVL
Newborns (37-41 wk gestational age, both sexes)/6 hypothermia 16 normothermia 15 control group
To evaluate OS in asphyxiated infants and to determinate if hypothermia treatment has an effect on OS
The ROM/BAP ratio values gradually increased after birth in hypothermia and normothermia cases. After 7 days, the ratio was higher in normothermia cases.
Hypothermia attenuated the OS in asphyxiated newborns.
Children (2-15 y, both sexes)/16 IMD patients 10 BA patients
Assess the differences in OS between pediatric patients undergoing living-related liver transplantation due to inherited metabolic disease (IMD) or biliary atresia (BA)
The ROM/BAP ratio was higher in the IMD group.
Patients who receive living-related liver transplantation due to IMD are prone to higher ROM/BAP ratio.
Adults ( and , both sexes)/12 females in acute stress condition 24 subjects in subacute fatigue condition 121 at-rest condition
Use dROMs and BAP to discriminate patients with chronic fatigue syndrome (CFS) from healthy volunteers experiencing acute and subacute fatigue, and at rest
The ROM/BAP ratio was higher after subacute fatigue. Resting condition produced higher ratio in patients with CFS than in healthy volunteers.
The markers might be useful for discriminate acute, subacute, and resting fatigue in healthy people and CFS patients.
Adults (17-57 y, both sexes)/42 patients with active CD in treatment with anti-TNF-α antibodies
Effect of antitumor necrosis factor (TNF)-α treatment on OS in Crohn’s disease (CD) patients. It used a modified BAP/dROMs ratio (m-BAP/dROMs ratio).
Negative correlation between m-BAP/dROMs ratio and CD activity index before and after treatment. The ratio did not differ between the patients before treatment.
Anti-TNF-α therapy decreases OS in patients with CD but does not modify the antioxidant production.
Older adults (, both sexes)/72 AD patients 27 with VaD 24 with MD 53 nondemented patients
OS differs in the pathophysiology and cognitive decline of Alzheimer’s disease (AD), vascular dementia (VaD), and mixed Alzheimer’s/vascular dementia (MD).
BAP/dROM ratios were lower in the AD and MD groups than control. The minimental state scores correlated with the ratio in the AD patients.
An imbalance in oxidant/antioxidant defenses may be involved in the pathophysiology of the AD and MD.