Rosiglitazone Suppresses Calcium Oxalate Crystal Binding and Oxalate-Induced Oxidative Stress in Renal Epithelial Cells by Promoting PPAR-γ Activation and Subsequent Regulation of TGF-β1 and HGF Expression

Figure 5

Representative immunohistochemistry images of kidney tissues. (a) Level of TGF-β1 was decreased in the RSG-treated group, while accumulation of HGF and p-Met by IHC staining in the RSG group was higher than that in the EG-induced rat model (×200). (b–d) Immunohistochemical expressions of TGF-β1, HGF, and p-Met were evaluated by densitometric analysis. The quantitative results are expressed as the of three experiments. N: normal; EG: ethylene glycol; R: rosiglitazone; G: GW9662; D: day. , , and versus the control group; ^### versus EG group; ^▽, ^▽▽, and ^▽▽▽ versus the RSG-treated group.

(a)

(b)

(c)

(d)