Carnosol Improved Lifespan and Healthspan by Promoting Antioxidant Capacity in Caenorhabditis elegans

Figure 5

Effects of carnosol on other physiological functions of C. elegans. (a) Fluorescence representation of age pigments is shown. (b) Carnosol effectively suppressed age pigment accumulation on days 6, 10, and 14. (c) Similar results were obtained by measuring the relative fluorescence of age pigments using a microplate reader. (d) Representative images of lipids stained with Oil Red O are shown. (e) Quantitative analysis of Oil Red O staining intensity revealed no significant change in fat content. (f) Curves of the Aβ-induced paralysis of CL4176. The number of paralyzed CL4176 animals was counted every 2 hours. (g) PolyQ-dependent paralysis curve of the AM140 mutant. Paralyzed individuals were recorded daily.

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