Carnosol Improved Lifespan and Healthspan by Promoting Antioxidant Capacity in Caenorhabditis elegans

Table 1

Statistical analysis of the survival time of C. elegans.

Genotype	Treatment^1	Mean time^2	Median time^3	Maximum time^4	% effect^5	value^6	Uncensored/
N2	0 μM	^a	^a	^a	—	—	159/180
	180 μM	^b	^b	^b	19	<0.0001	159/180
	0 μM (paraquat)	^a	^a	^a	—	—	134/180
	180 μM (paraquat)	^b	^b	^b	21	<0.0001	142/180
	0 μM (35°C)	^a	^a	^a	—	—	180/180
	180 μM (35°C)	^b	^b	^b	9	<0.0001	180/180
daf-16	0 μM	^a	^a	^a	—	—	137/180
	180 μM	^b	^b	^b	12	<0.0001	142/180
hsf-1	0 μM	^a	^a	^a	—	—	151/180
	180 μM	^a	^a	^a	—	0.8294	143/180

¹The control groups for stress resistance and the lifespan of mutants (daf-16 and hsf-1) were referred to previously published data [12]. ², where is the age category, is the number of worms that died in the age interval , and is the total number of worms. ³The median lifespan is the time at which the percentage of surviving worms equals 50%. ⁴The maximum lifespan is the time at which survival equals 0%. ⁵% effect was calculated by , where is the mean survival time of worms treated with carnosol and is the mean survival time of the control. ⁶The value was calculated using the log-rank test by comparing the carnosol-treated group with the control.