Potential Role of Nutrient Intake and Malnutrition as Predictors of Uremic Oxidative Toxicity in Patients with End-Stage Renal Disease

Table 8

Comparison between the areas under the ROC curve of malondialdehyde (MDA) and protein carbonyl (PCn) in relation to body mass-adjusted carbohydrate dietary intake, energy-adjusted zinc dietary intake, and blood antioxidant parameters.

Test result	AUC	SEM	CI (95%)	value
MDA (μg/mol pt)
CHO (g/kg/d)	0.5737	0.1010	0.3757–0.7718	0.4328
Zinc dietary intake (mg/d)	0.5253	0.09796	0.3333–0.7174	0.7874
Serum zinc (μg/L)	0.9954	0.00624	0.9832–1.008	<0.0001
GPx (nmol/[ml/min.])	0.9055	0.04995	0.8076–1.003	<0.0001
TAC (mM)	0.9608	0.02535	0.9111–1.011	<0.0001
npAC (mM)	0.8018	0.06524	0.6740–0.9297	0.0013
PCn (nmol/mg pt)
CHO (g/kg/d)	0.5455	0.08794	0.3731–0.7179	0.6015
Zinc dietary intake (mg/d)	0.5632	0.08736	0.3920–0.7345	0.4675
Serum zinc (μg/l)	0.8913	0.04949	0.7943–0.9883	<0.0001
GPx (nmol/[ml/min.])	0.7806	0.06761	0.6481–0.9132	0.0012
TAC (mM)	0.7115	0.08034	0.5540–0.8690	0.0151
npAC (mM)	0.6581	0.08248	0.4964–0.8198	0.0693

Values adjusted by the residual method. CHO: carbohydrate; GPx: glutathione peroxidase; TAC: total antioxidant capacity; npAC: nonprotein antioxidant capacity; AUC: area under the curve; SEM: mean standard error; CI: confidence interval. Values of in bold indicate statistical significance of AUC obtained from individual predictors of MDA and PCn levels ().