A Proteomic Network Approach across the Kidney Stone Disease Reveals Endoplasmic Reticulum Stress and Crystal-Cell Interaction in the Kidney

Figure 3

The ER stress-specific caspase was involved in apoptosis induced by COM crystals. Apoptotic cells were detected by the TUNEL and Hoechst assay (a). COM crystal exposure significantly increased apoptotic cell numbers () compared with the control group (b). The ER stress-specific caspase-12, caspase-3, phospho-JNK (P-JNK), and phospho-P38 (P-P38) expression was all detected in a time-dependent manner using a western blot (c–g). , .

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