Research Article

A Proteomic Network Approach across the Kidney Stone Disease Reveals Endoplasmic Reticulum Stress and Crystal-Cell Interaction in the Kidney

Figure 5

Marker proteins of ER stress expressed changes in rats treated with 0.75% EG from day zero to eight weeks. Crystals were formed from the 2nd week. The red arrow points to the crystal (a). The Bip/GRP78, CHOP, phospho-PERK (P-PERK), ATF6, caspase-3, and caspase-12 were activated (b). XBP-1 was spliced (c).
(a)
(b)
(c)