Integrative Bioinformatics Analysis Revealed Mitochondrial Dysfunction-Related Genes Underlying Intervertebral Disc Degeneration

Figure 2

Genes related to mitochondrial dysfunction. (a): box plot and PCA of gene expressions before and after batch effect removal in the GEO data. (b): correlations among mitochondrial dysfunction genes. Colors indicate correlations. A pinker color means stronger correlation. Node size indicates -log10 (P-value), and a larger node means higher significance. (c): volcano plots of DEGs, x-axis: log2FoldChange, y-axis: -log10 (adjust P-value); red, gray and blue nodes indicate the differentially expressed genes are upregulated, insignificant, and downregulated, respectively. (d): heat maps of DEGs, blue: degeneration group, red: control group. (e): histograms of expressions of mitochondrial dysfunction genes in test group and control group; x-axis: mitochondrial dysfunction genes, y-axis: gene expression level; red: test group, blue: control group. P <0.05: significant level. (f): PPI network of mitochondrial dysfunction genes.

(a)

(b)

(c)

(d)

(e)

(f)