Abatacept: A Promising Repurposed Solution for Myocardial Infarction-Induced Inflammation in Rat Models

Figure 1

Schematic representation of study protocol. Investigation of cardioprotective potential of Abatacept was performed using myocardial necrosis model where a dose of Abatacept was optimized, and thereafter, an optimized dose of Abatacept was used in the model of myocardial infarction ischemia injury. NS, normal saline; ISO-C, isoproterenol control; ABT2.5 + ISO, Abatacept 2.5 mg/kg + isoproterenol; ABT5 + ISO, Abatacept 5 mg/kg + isoproterenol; ABT10 + ISO, Abatacept 10 mg/kg+isoproterenol; IR-C, ischemia reperfusion control; Telmi10 + IR, telmisartan 10 mg/kg + ischemia reperfusion; ABT5 + IR, Abatacept 5 mg/kg + ischemia reperfusion.