Abatacept: A Promising Repurposed Solution for Myocardial Infarction-Induced Inflammation in Rat Models

<div>Effect of Abatacept on hemodynamic parameters in ISO-induced model of myocardial necrosis: SAP (a), MAP (b), DAP (c), HR (d), (±) LVdP/dtmax (e and f), and LVEDP (g). 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SAP, systolic arterial pressure; MAP, mean arterial pressure; DAP, diastolic arterial pressure; HR, heart rate; (+) LVdP/dt, left ventricular (positive) maximal rate of change of pressure; (−) LVdP/dt, left ventricular (negative) maximal rate of change of pressure; LVEDP, left ventricular end-diastolic pressure; ISO-C, isoproterenol control; ABT2.5 + ISO, Abatacept 2.5 mg/kg+isoproterenol; ABT5 + ISO, Abatacept 5 mg/kg + isoproterenol; ABT10 + ISO, Abatacept 10 mg/kg + isoproterenol.</div>

Oxidative Medicine and Cellular Longevity

fig2

Figure 2

Figure 2: Abatacept: A Promising Repurposed Solution for Myocardial Infarction-Induced Inflammation in Rat Models 