Abatacept: A Promising Repurposed Solution for Myocardial Infarction-Induced Inflammation in Rat Models

<div>Effect of Abatacept on TUNEL assay in ISO-induced rat model of myocardial necrosis. (a) Protein expression of PARP-cytochrome-C, (b) Nrf−2/HO−1, and (c) in ISO-induced rat model of myocardial necrosis. 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ISO-C, isoproterenol control; ABT2.5+ISO, Abatacept 2.5 mg/kg+isoproterenol; ABT5+ISO, Abatacept 5 mg/kg+isoproterenol; ABT10+ISO, Abatacept 10 mg/kg+isoproterenol; PARP, poly (ADP-ribose) polymerases; Nrf-2, nuclear factor erythroid 2-related factor 2; HO-1, heme oxygenase-1; TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling.</div>

Oxidative Medicine and Cellular Longevity

fig5

Figure 5

Figure 5: Abatacept: A Promising Repurposed Solution for Myocardial Infarction-Induced Inflammation in Rat Models 