Abatacept: A Promising Repurposed Solution for Myocardial Infarction-Induced Inflammation in Rat Models

Figure 6

(a) Effect of Abatacept on biochemical parameters in IR injury model; GSH (a-A), MDA (a-B), SOD (a-C), CAT (a-D), and cardiac injury markers CK-MB (a-E), LDH (a-F), data are expressed as mean ± SEM; n = 6 in each group. (b) Tissue histopathology with scoring (A–F) in ischemia-reperfusion (IR) injury model of myocardial infarction. (A) Normal; (B) IR-C, (C) Telmi10+IR, (D) ABT5 + IR, (E) ABT perse. (F) Grading for necrosis, edema, and inflammation: (+++) severe; (++) moderate; (+) mild; (−) no. , , and . GSH, glutathione; MDA, malondialdehyde; SOD, superoxide dismutase; CAT, chloramphenicol acetyltransferase; CK-MB, creatine kinase-myocardial band; LDH, lactate dehydrogenase; IR-C, ischemia-reperfusion control; Telmi10 + IR, telmisartan 10 mg/kg + ischemia-reperfusion; ABT5 + IR, Abatacept 5 mg/kg + ischemia-reperfusion.

(a)

(b)