Abatacept: A Promising Repurposed Solution for Myocardial Infarction-Induced Inflammation in Rat Models

Table 1

Biochemical evaluation of oxidant-antioxidant and cardiac injury markers in ISO induced model of myocardial necrosis.

Groups	GSH (mg/g of tissue)	MDA (µM/g of tissue)	SOD (U/mg of protein)	CAT (U/ml)	CK-MB (U/l)	LDH (U/l)
Normal	6.03 ± 0.62	0.34 ± 0.03	12.48 ± 0.63	6.28 ± 0.45	350.3 ± 17.15	323.8 ± 15.20
ISO-C	3.19 ± 0.38	0.62 ± 0.02	6.38 ± 0.52	2.15 ± 0.61	698.2 ± 47.63	701.9 ± 53.17
Abata2.5 + ISO	4.90 ± 0.73	0.48 ± 0.04^#	7.53 ± 0.38	4.61 ± 0.38^#	491.9 ± 35.73^###	605.2 ± 52.38^###
Abata5 + ISO	5.82 ± 0.36^#	0.41 ± 0.02^###	10.10 ± 0.46^###	5.2 ± 0.51^##	372.6 ± 20.62^###	498.3 ± 19.52^###
Abata10 + ISO	6.1 ± 0.82^#	0.39 ± 0.03^###	11.48 ± 0.62^###	5.8 ± 0.31^###	341.3 ± 23.46^###	443.4 ± 21.30^###

, , . ISO-C, isoproterenol control; ABT2.5+ISO, Abatacept 2.5 mg/kg+isoproterenol; ABT5+ISO, Abatacept 5 mg/kg+isoproterenol; ABT10+ISO, Abatacept 10 mg/kg + isoproterenol; GSH, glutathione; MDA, malondialdehyde; SOD, superoxide dismutase; CAT, catalase; CK-MB, creatine kinase−myocardial band; LDH, lactate dehydrogenase.