Abatacept: A Promising Repurposed Solution for Myocardial Infarction-Induced Inflammation in Rat Models

Table 2

Effect of Abatacept on hemodynamic parameters (MAP, HR, LVEDP, (±) LVdP/dt) at various time intervals in ischemia-reperfusion (IR) injury model of myocardial infarction.

Groups	MAP (mmHg)	Heart rate (bpm)	LVEDP	Positive LVdP/dt (mmHg/s)	Negative LVdP/dt (mmHg/s)
Baseline (0 min)
Sham	92.6 ± 2.0	375.3 ± 3.4	3.2 ± 0.1	2,100.9 + 18.9	1,787.5 ± 12.7
IR-C	92.5 ± 1.8	374.7 ± 1.4	3 ± 0.1	2,110.5 ± 24.6	1,795.2 ± 7.8
Telmi10 + IR	95.1 ± 1.3	375.5 ± 3.1	3.4 ± 0.1^#	2,081.2 ± 16.2	1,782.9 ± 12.4
ABT5 + IR	95.9 ± 0.7	377.2 ± 2.1	3.1 ± 0.1	2,104.3 ± 15.1	1,796.8 ± 10.4
ABT perse	95.6 ± 0.6	374.5 ± 2.9	2.9 ± 0.1	2,061.5 ± 26.5	1,784.8 ± 8.6
Ischemia (0 min)
Sham	89.7 ± 1.7	378 ± 2.1	3.2 ± 0.1	2,101.7 ± 21.3	1,780 ± 12.8
IR-C	68.4 ± 1.6	292.7 ± 2.1	6.3 ± 0.1	1,864.6 ± 17.8	1,578 ± 31.1
Telmi10 + IR	74.8 ± 1.4^/#	334.6 ± 4.3^/###	4 ± 0.2^/###	1,978.6 ± 15.2^/##	1,686 ± 18.7^/#
ABT5 + IR	75.7 ± 0.9^s/##	327.9 ± 3.3^/###	3.7 ± 0.1^###	1,960.4 ± 11.9^/#	1,714.6 ± 28^##
ABT perse	87.4 ± 0.5^###/$$$	369.4 ± 4^###/$$$	3 ± 0.1^###/$$$	2,095 ± 27.2^###/$$	1,766.2 ± 10.6^###
Ischemia (30 min)
Sham	89.2 ± 2.1	370 ± 2.4	3.2 ± 0.1	2,076.5 ± 23.7	1,765.8 ± 13
IR-C	70.7 ± 2.0	302.2 ± 2.9	6.6 ± 0.1	1,775 ± 16.2	1,581.2 ± 14.7
Telmi10 + IR	77.7 ± 1.2^/#	349.1 ± 3.2^/###	4.5 ± 0.2^/###	1,962 ± 13.6 ^/###	1,642.8 ± 22.3
ABT5 + IR	78.4 ± 0.7^/##	350.8 ± 4.4^###	4.1 ± 0.1^/###	1,949.4 ± 13.9^/###	1,691.4 ± 21.3^/###
ABT perse	88.6 ± 0.7^###/$$$	363.3 ± 4.5^###	3 ± 0.1^###/$$$	2,039.3 ± 31.5 ^###	1,769.9 ± 9.2^###/$$$
Ischemia (60 min)/reperfusion (0 min)
Sham	90.2 ± 2.2	370.5 ± 1.8	3.3 ± 0.1	2,068.4 ± 22.5	1,739.1 ± 13.3
IR-C	74.4 ± 2.3	320.4 ± 2.4	6.9 ± 0.1	1,817.6 ± 20.8	1,531.1 ± 28.3
Telmi10 + IR	82.7 ± 0.9^/##	318.7 ± 4.3	5 ± 0.1^/###	1,961.3 ± 14.6^/###	1,590.3 ± 17.5
ABT5 + IR	79.7 ± 0.9	326.4 ± 2.8	4.6 ± 0.1^/###	1,933.3 ± 11.1^/##	1,621.6 ± 21.1^/#
ABT perse	89.7 ± 0.6^###/$	361 ± 4.2^###/$$$	3 ± 0.1^###/$$$	2,030.5 ± 25.5^###	1,774.7 ± 8.8^###/$$$
Reperfusion (45 min)
Sham	86.4 ± 2.2	365.4 ± 1.7	3.3 ± 0.1	2,064.8 ± 21.6	1,732.6 ± 13
IR-C	71.2 ± 2.0	268.4 ± 0.9	7.2 ± 0.1	1,757.8 ± 20.2	1,451.8 ± 16.7
Telmi 10 + IR	78.3 ± 0.8^/#	321.6 ± 3^/###	5.4 ± 0.1^/###	1,970.8 ± 22^/###	1,576.8 ± 18.2^/###
ABT5 + IR	77.4 ± 1.2^/#	317.9 ± 1.8^/###	5.1 ± 0.1^/###	1,911.5 ± 13.9^/###	1,589.5 ± 17.4^/###
ABT perse	80.6 ± 0.6^##	360.8 ± 3.1^###/$$$	3 ± 0.1^###/$$$	2,009.8 ± 28.8^###	1,776.5 ± 9^###/$$$

, , . IR-C, ischemia reperfusion control, Telmi10+IR, telmisartan 10 mg/kg+ischemia reperfusion; ABT5+IR, Abatacept 5 mg/kg+ischemia reperfusion.