Stresses, Aging, and Age-Related Disorders
1Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, East China Normal University, Shanghai, China
2Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA
3Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston Medical School, Houston, TX, USA
4Department of Genetics and Biochemistry, Clemson University, Clemson, SC, USA
5Department of Head and Neck Surgery-Research, UT MD Anderson Cancer Center, Houston, TX, USA
Stresses, Aging, and Age-Related Disorders
Description
Oxidative stress and all other stresses that induce DNA damage are common causes in aging and in the development of age-related diseases. In more than 50 years, great strides have been made to understand the role of stresses and DNA damage in human health and diseases. In addition, damage to RNA, protein, and lipids resulted from oxidative stress may also contribute to aging and age-related disorders, including inflammation, neurodegeneration, or cancer. Studies and knowledge in these areas have greatly enhanced our understanding of the role oxidative and other stresses play in aging and other disease processes. We invite authors to submit original research as well as review articles that contribute to new insights of regulation and molecular mechanisms involved in biological actions under oxidative stress, DNA damage, DNA repair, aging, and age-associated disorders. We encourage articles that explore these aspects in humans and in animal models. Potential topics include, but are not limited to:
- Impact of oxidative and other stresses on cellular biological processes, such as transcription, translation, and protein stability
- Roles of stress-induced DNA damage on cell senescence
- New mechanisms by which DNA repair defects affect aging
- Development of new model systems in aging study
- Recent advances in antiaging drug discovery
- Identification of premature aging markers
- Discoveries in age-related disorders
- Positive stresses such as heat shock and hypoxia
Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/omcl/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/omcl/sag/ according to the following timetable: