Hydrogen sulfide (H₂S) is an endogenous biological mediator. The physiological importance of H₂S became recognized in the last two decades. It has been demonstrated that H₂S mediates many physiological functions in various biological systems including cardiovascular, central nervous and reproductive systems, kidneys, and lungs. Alteration of endogenous H₂S production was found in various diseases. Exogenous application of H₂S may protect cell function against ischemic and oxidant injuries. Recent advances in biology and medicine indicate that H₂S and its generating enzymes could be new targets to treat human diseases.

We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the biogenesis, metabolism, and biological functions of H₂S and other related sulfide-containing compounds.

Potential topics include, but are not limited to:

• Recent development in biosynthesis and metabolism of H₂S
• Advances in physiological and pathological functions of H₂S
• New methods for detection of endogenous and exogenous H₂S
• Interaction among different gaseous mediators
• Biological functions of polysulfide and SO₂
• Current understanding of protein sulfhydration
• Signaling mechanisms underlying the H₂S functions
• New development in H₂S releasing compounds
• Prospect of sulfide-containing compounds and H₂S synthesis inhibitors as therapeutic drugs