Oxidative Stress in Cardiovascular Pathologies: Genetics, Cellular, and Molecular Mechanisms and Future Antioxidant Therapies
1Department of Molecular Biology and Pharmacology, Institute of Cellular Biology and Pathology “Nicolae Simionescu”, 8 B.P. Hasdeu Street, Bucharest, Romania
2Division of Cardiovascular Sciences, Center for Applied Medical Research, University of Navarra, Pio XII 55, 31008 Pamplona, Spain
3Vascular Research Laboratory, Fundación Jiménez Diaz, Avenida Reyes Católicos 2, 28040 Madrid, Spain; Autonomous University of Madrid, 28049 Madrid, Spain
Oxidative Stress in Cardiovascular Pathologies: Genetics, Cellular, and Molecular Mechanisms and Future Antioxidant Therapies
Description
Eukaryotic cells constantly face the formation of reactive oxygen species (ROS) as a result of their aerobic metabolism. ROS play an important role in the regulation of signal transduction pathways and gene expression but its overproduction is acutely harmful to cells, particularly in cardiovascular diseases by a mechanism that is not fully understood. Therefore, uncovering the molecular mechanisms of ROS formation and function is a prerequisite of an effective antioxidative stress therapy. Oxidative stress is a common occurrence in most pathologies, that is, atherosclerosis, hypertension, diabetes, obesity, abdominal aortic aneurism, neurodegenerative diseases, cancer, and so forth. Despite the numerous existing data, an open area in the field is the “fine-tuning” mechanisms of oxidative stress-induced vascular inflammation and injury. Thus, the topic of this special issue focuses on the recent advances in experimental and clinical aspects of oxidative stress in cardiovascular disorders.
We invite researchers to contribute original research articles as well as review articles that will stimulate the ongoing efforts to identify the basic molecular mechanisms regulating the oxidative stress that will be used to find ways to manage its occurrence and correct its adverse effects. Potential topics include, but are not limited to:
- Reactive oxygen species formation and function in cardiovascular system
- Antioxidant mechanisms
- Cellular and molecular aspects of oxidative stress in cardiovascular cells
- Experimental models and approaches for the study of oxidative stress
- Biomarkers of oxidative stress
- Genetics of oxidative stress
- Clinical aspects of oxidative stress in cardiovascular diseases
- Recent advances in antioxidant therapies
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