In the last two decades, an increasing number of reports have indicated the remarkable roles of gasotransmitters in biology and medicine. Gasotransmitter is a group of small gaseous molecules, including nitric oxide (NO), hydrogen sulfide (H₂S), and carbon monoxide (CO). Gasotransmitter has higher lipid solubility and can penetrate easily through cell membranes without using any specific transporter/receptor. Not only from the environment, gasotransmitter can also be endogenously generated by specific enzymes and generates various functions at physiologically relevant concentrations by targeting at specific cellular and molecular sites. Abnormal generation and metabolism of these gasotransmitters have been extensively demonstrated to be linked to diverse biological processes, such as vascular biology, immune functions, cellular survival, metabolism, longevity, and development and stress resistance.

In this specific issue, we cordially invite authors to contribute original research articles as well as review articles highlighting the novel discoveries and recent progress in relation to the molecular mechanisms and drug targets of gasotransmitters in biology and medicine as well as the involvement of gasotransmitters in response to environmental stress in plant.

Potential topics include, but are not limited to:

• Gasotransmitters and cellular response to oxidative stress
• The molecular mechanisms of gasotransmitters in both health and disease
• The chemical and biochemical basis of gasotransmitters in cellular functions
• Novel donors and detection methods for gasotransmitters
• Generation, regulation, and metabolism of gasotransmitters in diverse biological systems
• Targeting gasotransmitters for therapeutic purposes