Mitochondria are complex cellular organelles with an increasingly known relevance in our cells. Nowadays, besides being central to ATP production and energy metabolism, mitochondria are considered key mediators in a wide variety of cellular functions that definitely influence cellular fate, including programmed cell death. Therefore, investigating mitochondrial function has become central to numerous areas of biomedical research. Cell biologists, biochemists, neuroscientists, exercise physiologists, and clinicians are working together to fully appreciate this challenging field of investigation. Thus, it appears that the understanding of mitochondrial function and its crosstalk with other cellular organelles may be critical to unraveling the underlying cellular and molecular mechanisms associated with a variety of pathophysiological conditions. Further knowledge on mitochondrial biology is fundamental both in health and disease.

We invite authors to submit original research and review articles that seek to refine the interactions of several physiological stimuli and pathophysiological conditions with mitochondrial function. Potential topics include, but are not limited to:

• Recent discoveries in mitochondrial network and dynamic organization
• Current developments on the effects of caloric restriction in mitochondrial bioenergetics
• New insights concerning the impact of exercise on mitochondrial plasticity
• Relevance of mitochondria as O₂ sensors and ROS sources under hypoxic conditions
• Current research on age-related disorders and mitochondrial function
• Current knowledge on the implications of mitochondria in apoptotic cell signaling
• Advanced research on mitochondriopathies characterizing disease states or pharmacological interactions of drugs with tissue and mitochondrial structure, biochemistry, and function
• Recent developments in mitochondrial medicine and therapeutics targeting the mitochondrion

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/oximed/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable: