Hypoxia-Induced Oxidative Stress in Health Disorders
1Centre de Recherche et d'Innovation sur le Sport, Université Claude Bernard Lyon 1, 69100 Villeurbanne, France
2Neurovascular Research Laboratory, Faculty of Health, Sport and Science, University of Glamorgan, Mid Glamorgan CF37 1DL, UK
3Équipe Génétique et physiopathologie de Maladies Neurodéveloppementales et Neuromusculaires, Institut Cochin, UMR CNRS, INSERM, Université Paris Descartes, 75270 Paris Cédex 06, France
Hypoxia-Induced Oxidative Stress in Health Disorders
Description
Hypoxia exposure per se can lead to altitude mountain sicknesses and sometime to high-altitude pulmonary or cerebral oedemas when the exposure is severe. Chronic intermittent hypoxia, which is a common and life-threatening condition that occurs in many different diseases, has been shown to promote hypertension, and consequent cardio- and cerebrovascular diseases but also metabolic disorders such as diabetes and atherosclerosis. Finally, recent studies suggest that hypoxia can be one the underlying mechanisms of the atherogenesis and carcinogenesis. The oxidative stress that occurs during intermittent or continuous cellular hypoxia seems to play a major role in the pathogenesis of all these diseases.
We invite investigators to submit original research articles as well as review articles that will focus on the role of oxidative stress hypoxia-induced in cardiovascular, respiratory, and metabolic diseases. We are particularly interested in papers that will improve the understanding of the molecular and cellular pathological mechanisms involved in the causes and outcomes of the reactive oxygen species overproduced in all the forms of hypoxia. Potential topics include, but are not limited to:
- Role of oxidative stress in chronic intermittent hypoxia conditions in pathogenesis of cardiovascular, respiratory, and metabolic disorders
- Redox cellular mechanisms associated with hypoxia during aging and in the development of cancer and atherosclerosis
- How free radicals can mediate ventilatory and cardiac adaptation in hypoxia
- Identifying mechanisms related to oxidative stress involved in altitude diseases
- Cellular defense mechanisms against hypoxia-induced oxidative stress
- Development of therapeutic strategy in order to limit oxidative stress in ischemia/hypoxia-related diseases such as intermittent hypoxia exposure
Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/oximed/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable: