Oxidative stress has been recognized as a major player in the pathophysiology of several cardiovascular diseases including hypertension, coronary artery disease, atherosclerosis, cardiomyopathy, and heart failure. Many haemodynamic and neurohumoral changes occur in response to different pathologic stimuli, contributing to cardiac remodeling that may ultimately lead to heart failure. In this process, the renin angiotensin system, sympathetic nervous system, immune activation, inflammation, and oxidative stress play an important role. Oxidative damage may appear as a consequence of increased production of reactive oxygen species (ROS). Antioxidant systems act to counterregulate ROS concentrations and consequently can modulate oxidative injury. The disturbance between the proantioxidant and antioxidant balance may determine an oxidative stress condition. Furthermore ROS also function as signaling molecules influencing various cardiovascular outcomes. Thus, given that the equilibrium between pro- and antioxidants is important for targeting intracellular signaling pathways, the understanding of this balance is crucial for identifying appropriate therapeutic strategies.

The purpose of the topic is to assemble information from animal as well as human studies in order to provide an additional opportunity to identify the molecular mechanisms involved in the pathogenesis of heart disease. We invite investigators to contribute to original research articles as well as review articles that address novel mechanistic insights into the role of oxidative stress in cardiovascular disease. We are particularly interested in the articles highlighting new therapeutic strategies of antioxidant delivery. Potential topics include, but are not limited to:

• Role of oxidative stress in the pathogenesis of heart failure
• Role of endoplasmic reticulum and mitochondria in cardiovascular disease
• Interplay between inflammation and oxidative stress in the development of cardiovascular disease
• Role of oxidative stress in endothelial dysfunction
• Role of redox signaling in epigenetics and cardiovascular disease
• Role of antioxidants in various models of heart failure and in humans
• Novel therapeutic interventions for heart failure and endothelial dysfunction

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