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Yeast Stress, Aging, and Death

Call for Papers

Until about 15 years ago, programmed cell death, at that time mainly defined as apoptosis, was believed to be a feature occurring only in metazoans to ensure proper embryonic development, cell differentiation, and regulation of the immune response. However, the discovery that single-celled organisms, such as yeast, undergo programmed cell death as well challenged this idea. Meanwhile, several key regulators and cell death executers were shown to be highly conserved in yeast and other unicellular organisms, and it is now generally accepted that at least part of the molecular cell death machinery originated early in evolution.

Approximately 31% of the yeast genes have a mammalian homologue, and an additional 30% of yeast genes show domain similarity. This combined with the ease of manipulation of yeast and the elegance of yeast genetics has turned this lower eukaryote into an ideal system to study more complex phenomena that occur in metazoan cells, including stress responses, aging, and cell death as such or in the context of human diseases like cancer and neurodegenerative disorders.

We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the intimate links between the aforementioned processes. Potential topics include, but are not limited to:

  • Molecular factors and pathways contributing to cell death and/or aging
  • Mitochondrial function in stress response
  • Stress and death
  • Humanized yeast models
  • Aging and death networks, including approaches of systems biology
  • Prodeath and prolife cellular strategies
  • Oxidative damage and aging connections
  • Energy metabolism in stress, death and longevity

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/oximed/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/oximed/ysad/ according to the following timetable:

Manuscript DueFriday, 10 May 2013
First Round of ReviewsFriday, 2 August 2013
Publication DateFriday, 27 September 2013

Lead Guest Editor

  • Cristina Mazzoni, Department of Biology and Biotechnology “Charles Darwin”, Sapienza University of Rome, Piazzale Aldo Moro, Roma, Italy

Guest Editors

  • Sergio Giannattasio, Istituto di Biomembrane e Bioenergetica, Consiglio Nazionale delle Ricerche, Via Amendola 165°, 70126 Bari, Italy
  • Joris Winderickx, Functional Biology and BioSCENTer, Institute of Botany and Microbiology, K.U. Leuven, Kasteelpark Arenberg 31, Box 2433, 3001 Heverlee, Belgium
  • Paula Ludovico, Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal; ICVS/3B's, PT Government Associate Laboratory, Braga/Guimaraes, University of Minho Campus Gualtar, 4710-057 Braga, Portugal