| | Histone subtype | Protein | Localization | Main HDAC inhibitors |
| | Class I (Zn++-dependent) | HDAC1, 2, 3, and 8 | Mainly nucleus | Valproic acid, butyrate, vorinostat, trichostatin A, RGFP136 (HDAC3) | | Class IIa (Zn++-dependent) | HDAC4, 5, 7, and 9 | Nucleus/cytoplasm | Trichostatin A, phenylbutyrate | | Class IIb (Zn++-dependent) | HDAC6 and 10 | Mainly cytoplasm | Tubacin (HDAC6), trichostatin A | | ClassIII (NAD+-dependent) | SirT1, 2, 3, 4, 5, 6, and 7 | Nucleus/cytoplasm/Mitochondria | Nicotinamide, suramin (SirT1 and SirT2), | | Class IV (Zn++-dependent) | HDAC11 | Mainly nucleus | |
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