Table 2: Malonyldialdehyd and 4-hydroxynonenal concentration (nmol/g of cardiac sample;
𝑋
±
S
.
D
.) in rat cardiac homogenates 4, 48, and 96 h after doxorubicin administration.Time from DOX injection (h) DOX (mg/kg) or saline Methimazole (%) ANOVA 0.0000 0.001 (METL ) 0.025 (METH )
𝑃
4 2
2
8
.
0
1
±
3
.
0
7
3
0
.
3
3
±
4
.
0
6
2
9
.
1
2
±
4
.
7
3
0.6977 5
3
0
.
3
6
±
2
.
5
2
3
1
.
4
2
±
3
.
5
8
2
6
.
1
1
±
3
.
8
2
0.0706 15
3
1
.
8
1
±
3
.
6
7
3
5
.
2
1
±
7
.
4
0
3
3
.
9
3
±
4
.
0
9
0.7163 48 2
2
5
.
8
4
±
4
.
2
6
2
3
.
3
7
±
3
.
9
4
2
2
.
0
1
±
4
.
1
4
0.5945 5
2
6
.
8
5
±
1
.
3
9
2
5
.
0
6
±
3
.
9
0
2
5
.
8
4
±
0
.
9
6
0.6288 15
2
9
.
8
5
±
6
.
5
0
2
9
.
6
3
±
7
.
8
5
3
8
.
5
0
±
4
.
5
* 0.7520 96 2
3
1
.
3
6
±
1
0
.
4
5
2
2
.
4
3
±
1
.
9
9
#
2
8
.
4
9
±
4
.
8
3
0.0358 5
3
1
.
2
5
±
4
.
3
3
3
2
.
2
0
±
7
.
4
8
2
6
.
1
2
±
4
.
9
3
0.2535 15
3
9
.
3
6
±
3
.
3
9
*
3
5
.
4
3
±
4
.
3
8
4
4
.
9
9
±
1
3
.
8
7
* 0.2783 0.9% NaCl
𝟐
𝟒
.
𝟖
𝟗
±
𝟔
.
𝟕
𝟏
(control )
2
6
.
3
2
±
3
.
2
4
2
2
.
4
8
±
3
.
4
2
—
*
𝑃
<
0
.
0
5
versus control; # DOX + MET versus DOX.