Table 5:
Total glutathione concentration (nmol/g of cardiac sample;
𝑋
±
S
.
D
.) in rat cardiac homogenates 4, 48, and 96 h after doxorubicin administration.
Time from DOX injection (h)
DOX (mg/kg) or saline
Methimazole (%)
ANOVA
0.0000
0.001 (MET
L
)
0.025 (MET
H
)
𝑃
4
2
3
6
9
.
2
7
±
2
9
.
4
5
3
5
3
.
0
4
±
3
0
.
2
4
3
6
3
.
6
8
±
3
7
.
9
7
0.6505
5
4
0
5
.
8
3
±
7
7
.
7
6
3
5
6
.
6
6
±
2
6
.
2
8
3
9
4
.
1
6
±
3
9
.
1
5
0.3356
15
3
4
8
.
3
3
±
2
2
.
5
5
4
1
8
.
3
3
±
5
2
.
5
0
3
6
3
.
3
3
±
3
9
.
4
6
0.0514
48
2
3
6
1
.
5
4
±
4
3
.
7
6
3
9
5
.
5
2
±
3
1
.
9
2
3
7
8
.
8
5
±
2
9
.
8
2
0.4449
5
3
5
3
.
3
3
±
7
0
.
7
3
4
5
4
.
1
6
±
4
6
.
6
8
*,#
4
5
5
.
8
3
±
4
1
.
1
0
*,#
0.0418
15
3
9
5
.
8
3
±
6
9
.
5
3
5
6
4
.
1
6
±
7
2
.
0
8
*,#
4
3
9
.
1
7
±
1
6
.
8
2
*,#,†
0.0080
96
2
3
3
9
.
1
6
±
4
3
.
1
6
3
2
8
.
3
3
±
2
7
.
5
4
3
6
2
.
5
0
±
3
5
.
8
4
0.2101
5
3
4
0
.
0
0
±
3
1
.
5
4
4
2
1
.
6
6
±
4
9
.
0
7
*
3
0
0
.
8
3
±
6
2
.
0
4
*,#,†
0.0081
15
3
2
2
.
9
2
±
5
5
.
5
4
3
6
7
.
7
1
±
3
4
.
4
2
3
6
5
.
0
0
±
3
8
.
1
4
0.3813
0.9% NaCl
𝟑
𝟔
𝟖
.
𝟑
𝟑
±
𝟑
𝟒
.
𝟒
𝟑
(
control
)
3
4
2
.
7
1
±
8
3
.
5
7
3
9
5
.
8
3
±
2
5
.
6
8
—
*
𝑃
<
0
.
0
5
versus control;
#
DOX + MET versus DOX;
†
DOX + MET
H
versus DOX + MET
L
.