Table 2:
Rate constants for the hydrolysis of codrugs
1-2
,
5
, and
9–14
in 80% rat plasma and 80% human plasma at 37°C.
Rat plasma
a
Human plasma
a
Compd
(min)
(min
−1
)
(min)
(min
−1
)
1
immediate hydrolysis
—
2
5
9
10
11
12
13
14
a
Values are means of three experiments, standard deviation is given in parentheses.