Table 6: Common differentially expressed genes in HT29 treated-cells.

Gene symbol FC absolute ICC value Regulation FC absolute CA value Regulation FST 1.343 0.025 Up 1.375 0.022 Up SULT1B1 1.349 0.018 Up 1.304 0.020 Up EPOR 1.372 0.008 Up 1.321 0.021 Up HINT3 2.410 0.040 Up 2.607 0.033 Up STAT5B 1.312 0.007 Up 1.334 0.012 Up GLS 1.335 0.001 Down 1.370 0.001 Down PPP3R1 1.397 0.023 Down 1.423 0.026 Down ATF2 1.481 0.005 Down 1.354 0.016 Down SLC4A7 1.314 0.029 Down 1.322 0.025 Down MARCH3 1.330 0.016 Down 1.319 0.005 Down TBL1XR1 1.426 0.001 Down 1.332 0.001 Down SAP30L 1.375 0.013 Down 1.405 0.021 Down FGD4 1.593 0.001 Down 1.523 0.027 Down ZDHHC20 1.665 0.004 Down 1.314 0.005 Down ZDHHC21 1.642 0.037 Down 1.318 0.016 Down FAM76B 1.506 0.014 Down 1.325 0.037 Down CLK4 1.326 0.049 Down 1.339 0.021 Down

Common differentially expressed genes in HT29 treated-cells with a value and a minimum fold of 1.3. Column ICC correspond to cells treated with instant caffeinated coffee and column CA corresponds to cells treated with caffeic acid. Overexpressed genes are indicated on the upper part of the table, whereas underexpressed genes are depicted in the lower part. The genes in bold, STAT5B and ATF-2, were chosen for further analysis.