Table 1: Functional categories of proteins identified as increasingly modified in aging and age-related diseases. Fisher exact test was used and the value refers to the probability that each biological function assigned is due to chance alone.

Function value Modified proteins Inflammatory response ACO2, ACTB, ALDH2, ALDOA, ARG1, ENO1, GAPDH, HSPA5, P4HB, PDIA3, PRDX1, PRDX6, SELENBP1, TKT, TPI1 Carbohydrate metabolism ALDOA, ENO1, ENO2, FBP1, GAPDH, PGAM1, PGK1, PKLR, PKM2, TPI1, ACADM Nucleic acid metabolism ACOT8, ALDH2, ATP5A1, ATP5B, CKM, DPYSL2, GNB1, SCP2, SUCLA2, MDH2 Cell death ACAT1, ANXA2, ARG1, ATP5A1, G6PD, G5TM5, HSPD1, SLC1A2, PIN1, PRDX2, PARK7, TUBA1A Lipid metabolism MDH1, MDH2, SDHA, SDHB, OGDH, SUCLA2, ACOT8, FABP4, GSTP1, SCP2 Free radical scavenging ALB, SOD1, SOD2, PRDX1, PRDX2, PRDX6, VDAC1, ALDH2, GPX1 Protein folding HSP90AA1, HSPA1A, ERP29, HSPD1, HSPA8, HSP90AB1 Amino acid metabolism ARG1, DDAH1, IVD, OAT, PAH, CKM, PLOD3 Protein synthesis EEF2, GNB2L1, RPS6KB1, TUFM, WARS, CCDC92 Cell migration AP2M1, FSCN1, GNB1, TPM1, VIM, ACTB, TAGLN2