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Oxidative Medicine and Cellular Longevity
Volume 2012 (2012), Article ID 929285, 15 pages
doi:10.1155/2012/929285
The Hypoxic Testicle: Physiology and Pathophysiology
1Instituto de Química, Facultad de Ciencias, Pontificia Universidad Católica de Valparaíso, 2340000 Valparaíso, Chile
2Departamento de Ingeniería Química, Facultad de Ingeniería, Ciencias y Administración, Universidad de La Frontera, 4780000 Temuco, Chile
3Departamento de Fisiología, Facultad de Ciencias Biológicas, Pontifica Universidad Católica de Chile, 8320000 Santiago, Chile
4Centro de Investigaciones Biomédicas, Escuela de Medicina, Universidad de Valparaíso, 2340000 Valparaíso, Chile
Received 5 May 2012; Revised 7 August 2012; Accepted 9 August 2012
Academic Editor: Vincent Pialoux
Copyright © 2012 Juan G. Reyes et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Linked References
- R. Wayne, Chemistry of Atmospheres, Oxford Science Publication, Clarendon Press, Oxford, UK, 1985.
- P. Hochachka, Living without Oxygen, Harvard University Press, London, UK, 1980.
- J. L. Rupert and P. W. Hochachka, “Genetic approaches to understanding human adaptation to altitude in the Andes,” Journal of Experimental Biology, vol. 204, no. 18, pp. 3151–3160, 2001. View at Scopus
- B. D'Autréaux and M. B. Toledano, “ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis,” Nature Reviews Molecular Cell Biology, vol. 8, no. 10, pp. 813–824, 2007. View at Publisher · View at Google Scholar · View at Scopus
- R. M. Leach and D. F. Treacher, “Oxygen transport—2. Tissue hypoxia,” British Medical Journal, vol. 317, no. 7169, pp. 1370–1373, 1998. View at Scopus
- R. Germack, F. Leon-Velarde, R. Valdes De La Barra, J. Farias, G. Soto, and J. P. Richalet, “Effect of intermittent hypoxia on cardiovascular function, adrenoceptors and muscarinic receptors in Wistar rats,” Experimental Physiology, vol. 87, no. 4, pp. 453–460, 2002. View at Scopus
- K. Abdulmalek, F. Ashur, N. Ezer, Y. Fengchun, S. Magder, and S. N. A. Hussain, “Differential expression of Tie-2 receptors and angiopoietins in response to in vivo hypoxia in rats,” American Journal of Physiology, vol. 281, no. 3, pp. L582–L590, 2001. View at Scopus
- H. H. Marti and W. Risau, “Systemic hypoxia changes the organ-specific distribution of vascular endothelial growth factor and its receptors,” Proceedings of the National Academy of Sciences of the United States of America, vol. 95, no. 26, pp. 15809–15814, 1998. View at Publisher · View at Google Scholar · View at Scopus
- N. P. Fam, S. Verma, M. Kutryk, and D. J. Stewart, “Clinician guide to angiogenesis,” Circulation, vol. 108, no. 21, pp. 2613–2618, 2003. View at Publisher · View at Google Scholar · View at Scopus
- C. Michiels, “Endothelial cell functions,” Journal of Cellular Physiology, vol. 196, no. 3, pp. 430–443, 2003. View at Publisher · View at Google Scholar · View at Scopus
- G. L. Semenza, “Hypoxia-inducible factor 1: control of oxygen homeostasis in health and disease,” Pediatric Research, vol. 49, no. 5, pp. 614–617, 2001. View at Scopus
- A. J. Giaccia, M. C. Simon, and R. Johnson, “The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease,” Genes and Development, vol. 18, no. 18, pp. 2183–2194, 2004. View at Publisher · View at Google Scholar · View at Scopus
- G. L. Semenza, “Hydroxylation of HIF-1: oxygen sensing at the molecular level,” Physiology, vol. 19, no. 4, pp. 176–182, 2004. View at Scopus
- R. K. Bruick, “Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factor,” Genes and Development, vol. 17, no. 21, pp. 2614–2623, 2003. View at Publisher · View at Google Scholar · View at Scopus
- C. W. Pugh and P. J. Ratcliffe, “Regulation of angiogenesis by hypoxia: role of the HIF system,” Nature Medicine, vol. 9, no. 6, pp. 677–684, 2003. View at Publisher · View at Google Scholar · View at Scopus
- R. H. Wenger, “Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression,” FASEB Journal, vol. 16, no. 10, pp. 1151–1162, 2002. View at Publisher · View at Google Scholar · View at Scopus
- G. L. Wang and G. L. Semenza, “Purification and characterization of hypoxia-inducible factor 1,” Journal of Biological Chemistry, vol. 270, no. 3, pp. 1230–1237, 1995. View at Publisher · View at Google Scholar · View at Scopus
- Y. Yuan, G. Hilliard, T. Ferguson, and D. E. Millhorn, “Cobalt inhibits the interaction between hypoxia-inducible factor-α and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-α,” Journal of Biological Chemistry, vol. 278, no. 18, pp. 15911–15916, 2003. View at Publisher · View at Google Scholar · View at Scopus
- M. P. Samuels, “The effects of flight and altitude,” Archives of Disease in Childhood, vol. 89, no. 5, pp. 448–455, 2004. View at Publisher · View at Google Scholar · View at Scopus
- P. Lindholm and C. E. G. Lundgren, “The physiology and pathophysiology of human breath-hold diving,” Journal of Applied Physiology, vol. 106, no. 1, pp. 284–292, 2009. View at Publisher · View at Google Scholar · View at Scopus
- P. W. Hochachka, “Molecular mechanisms of defense against oxygen lack,” Undersea Biomedical Research, vol. 16, no. 5, pp. 375–379, 1989. View at Scopus
- B. D. Kent, P. D. Mitchell, and W. T. Mcnicholas, “Hypoxemia in patients with COPD: cause, effects, and disease progression,” International Journal of COPD, vol. 6, no. 1, pp. 199–208, 2011. View at Publisher · View at Google Scholar · View at Scopus
- L. Lavie, “Oxidative stress inflammation and endothelial dysfunction in obstructive sleep apnea,” Frontiers in Bioscience, vol. 4, pp. 1391–1403, 2012. View at Scopus
- R. Luboshitzky, A. Aviv, A. Hefetz et al., “Decreased pituitary-gonadal secretion in men with obstructive sleep apnea,” Journal of Clinical Endocrinology and Metabolism, vol. 87, no. 7, pp. 3394–3398, 2002. View at Publisher · View at Google Scholar · View at Scopus
- G. F. Gonzales, “Peruvian contributions to the study on human reproduction at high altitude: from the chronicles of the Spanish conquest to the present,” Respiratory Physiology and Neurobiology, vol. 158, no. 2-3, pp. 172–179, 2007. View at Publisher · View at Google Scholar · View at Scopus
- J. P. Richalet, M. V. Donoso, D. Jiménez et al., “Chilean miners commuting from sea level to 4500 m: a prospective study,” High Altitude Medicine and Biology, vol. 3, no. 2, pp. 159–166, 2002. View at Publisher · View at Google Scholar · View at Scopus
- A. E. Abelson, T. S. Baker, and P. T. Baker, “Altitude, migration and fertility in the Andes,” Social Biology, vol. 21, no. 1, pp. 12–27, 1974. View at Scopus
- V. J. Vitzthum and A. D. Wiley, “The proximate determinants of fertility in populations exposed to chronic hypoxia,” High Altitude Medicine and Biology, vol. 4, no. 2, pp. 125–139, 2003. View at Publisher · View at Google Scholar · View at Scopus
- A. Okumura, H. Fuse, Y. Kawauchi, I. Mizuno, and T. Akashi, “Changes in male reproductive function after high altitude mountaineering,” High Altitude Medicine and Biology, vol. 4, no. 3, pp. 349–353, 2003. View at Publisher · View at Google Scholar · View at Scopus
- V. Verratti, F. Berardinelli, C. Di Giulio et al., “Evidence that chronic hypoxia causes reversible impairment on male fertility,” Asian Journal of Andrology, vol. 10, no. 4, pp. 602–606, 2008. View at Publisher · View at Google Scholar · View at Scopus
- K. E. Barnholt, A. R. Hoffman, P. B. Rock et al., “Endocrine responses to acute and chronic high-altitude exposure (4,300 meters): modulating effects of caloric restriction,” American Journal of Physiology, vol. 290, no. 6, pp. E1078–E1088, 2006. View at Publisher · View at Google Scholar · View at Scopus
- J. R. Gosney, “Effects of hypobaric hypoxia on the Leydig cell population of the testis of the rat,” Journal of Endocrinology, vol. 103, no. 1, pp. 59–62, 1984. View at Scopus
- H. M. Biswas, M. C. Boral, and A. K. Ghosh, “Effect of hypobaric hypoxia on spermatogenesis, Leydig cells and delta 5-3 beta-hydroxysteroid dehydrogenase activity in toad,” Indian Journal of Physiology and Pharmacology, vol. 29, no. 3, pp. 139–145, 1985. View at Scopus
- J. G. Farias, E. Bustos-Obregón, R. Orellana, J. L. Bucarey, E. Quiroz, and J. G. Reyes, “Effects of chronic hypobaric hypoxia on testis histology and round spermatid oxidative metabolism,” Andrologia, vol. 37, no. 1, pp. 47–52, 2005. View at Publisher · View at Google Scholar · View at Scopus
- J. G. Farías, E. Bustos-Obregón, and J. G. Reyes, “Increase in testicular temperature and vascularization induced by hypobaric hypoxia in rats,” Journal of Andrology, vol. 26, no. 6, pp. 693–697, 2005. View at Publisher · View at Google Scholar · View at Scopus
- E. Bustos-Obregón, C. Esveile, J. Contreras, I. Maurer, and L. Sarabia, “Effects of chronic simulated hypobaric hypoxia on mouse spermatogenesis,” International Journal of Morphology, vol. 24, no. 3, pp. 481–488, 2006. View at Scopus
- J. G. Farias, E. Bustos-Obregón, P. J. Tapia et al., “Time course of endocrine changes in the hypophysis-gonad axis induced by hypobaric hypoxia in male rats,” Journal of Reproduction and Development, vol. 54, no. 1, pp. 18–21, 2008. View at Publisher · View at Google Scholar · View at Scopus
- O. N. Shevantaeva and Y. I. Kosyuga, “Effect of acute hypobaric hypoxia on spermatogenesis and lactate concentration in testicular tissue of male albino rats,” Bulletin of Experimental Biology and Medicine, vol. 141, no. 1, pp. 20–22, 2006. View at Publisher · View at Google Scholar · View at Scopus
- W. Liao, M. Cai, J. Chen et al., “Hypobaric hypoxia causes deleterious effects on spermatogenesis in rats,” Reproduction, vol. 139, no. 6, pp. 1031–1038, 2010. View at Publisher · View at Google Scholar · View at Scopus
- G. F. Gonzales, L. Rodriguez, J. Valera, E. Sandoval, and M. Garcia-Hjarles, “Prevention of high altitude-induced testicular disturbances by previous treatment with cyproheptadine in male rats,” Archives of Andrology, vol. 24, no. 2, pp. 201–205, 1990. View at Scopus
- J. G. Farias, M. Puebla, A. Acevedo et al., “Oxidative stress in rat testis and epididymis under intermittent hypobaric hypoxia: protective role of ascorbate supplementation,” Journal of Andrology, vol. 31, no. 3, pp. 314–321, 2010. View at Publisher · View at Google Scholar · View at Scopus
- A. Vargas, E. Bustos-Obregón, and R. Hartley, “Effects of hypoxia on epididymal sperm parameters and protective role of ibuprofen and melatonin,” Biological Research, vol. 44, no. 2, pp. 161–167, 2011. View at Publisher · View at Google Scholar · View at Scopus
- J. G. Farías, A. B. Zepeda, and G. M. Calaf, “Melatonin protects the heart, lungs and kidneys from oxidative stress under intermittent hypobaric hypoxia in rats,” Biological Research, vol. 45, no. 1, pp. 81–85, 2012. View at Publisher · View at Google Scholar · View at Scopus
- S. Arena, L. Minutoli, F. Arena et al., “Polydeoxyribonucleotide administration improves the intra-testicular vascularization in rat experimental varicocele,” Fertility and Sterility, vol. 97, no. 1, pp. 165–168, 2012. View at Publisher · View at Google Scholar · View at Scopus
- M. Abbasi, R. Alizadeh, F. Abolhassani et al., “Effect of aminoguanidine in sperm DNA fragmentation in varicocelized rats: role of nitric oxide,” Reproductive Sciences, vol. 18, no. 6, pp. 545–550, 2011. View at Publisher · View at Google Scholar · View at Scopus
- D. Cheng, X. M. Zheng, S. W. Li, Z. W. Yang, and L. Q. Hu, “Effects of epidermal growth factor on sperm content and motility of rats with surgically induced varicoceles,” Asian Journal of Andrology, vol. 8, no. 6, pp. 713–717, 2006. View at Publisher · View at Google Scholar · View at Scopus
- R. Onur, A. Semerciöz, I. Orhan, and H. Yekeler, “The effects of melatonin and the antioxidant defence system on apoptosis regulator proteins (Bax and Bcl-2) in experimentally induced varicocele,” Urological Research, vol. 32, no. 3, pp. 204–208, 2004. View at Scopus
- P. Cao, J. X. Xue, R. P. Jia et al., “Effects of endothelial progenitor cells on spermatogenic functions in testicular detorsion in rats,” Zhonghua yi xue za zhi, vol. 91, no. 30, pp. 2135–2138, 2011.
- M. Kanter, “Protective effects of Ginkgo biloba (EGb 761) on testicular torsion/detorsion-induced ischemia-reperfusion injury in rats,” Experimental and Molecular Pathology, vol. 91, no. 3, pp. 708–713, 2011. View at Publisher · View at Google Scholar · View at Scopus
- H. Yildiz, A. S. Durmuş, H. Şimşek, and I. Yaman, “Effects of sildenafil citrate on torsion/detorsion-induced changes in red blood cell and plasma lipid peroxidation, antioxidants, and blood hematology of male rats,” European Journal of Obstetrics Gynecology and Reproductive Biology, vol. 159, no. 3, pp. 359–363, 2011. View at Publisher · View at Google Scholar · View at Scopus
- L. Minutoli, F. Squadrito, P. A. Nicotina et al., “Melanocortin 4 receptor stimulation decreases pancreatitis severity in rats by activation of the cholinergic anti-inflammatory pathway,” Critical Care Medicine, vol. 39, no. 5, pp. 1089–1096, 2011. View at Publisher · View at Google Scholar · View at Scopus
- S. M. Wei, Z. Z. Yan, and J. Zhou, “Protective effect of rutin on testicular ischemia-reperfusion injury,” Journal of Pediatric Surgery, vol. 46, no. 7, pp. 1419–1424, 2011. View at Publisher · View at Google Scholar · View at Scopus
- B. Akçora, M. E. Altuǧ, A. Balci et al., “Gradual detorsion of torsioned rat testis attenuates ischemia reperfusion injury,” Journal of Pediatric Surgery, vol. 43, no. 10, pp. 1879–1884, 2008. View at Publisher · View at Google Scholar · View at Scopus
- A. I. Dokucu, H. Ozturk, H. Ozturk, M. C. Tuncer, and F. Yilmaz, “The effects of molsidomine on hypoxia inducible factor alpha and Sonic hedgehog in testicular ischemia/reperfusion injury in rats,” International Urology and Nephrology, vol. 41, no. 1, pp. 101–108, 2009. View at Publisher · View at Google Scholar · View at Scopus
- B. G. Nezami, S. Rahimpour, T. Gholipour et al., “Protective effects of immunophilin ligands on testicular torsion/detorsion damage in rats,” International Urology and Nephrology, vol. 41, no. 1, pp. 93–99, 2009. View at Publisher · View at Google Scholar · View at Scopus
- M. Bozlu, D. Acar, S. Cayan, S. Aktas, and A. Tunckiran, “Protective effect of trapidil on long-term histologic damage in a rat model of testicular ischemia-reperfusion injury,” World Journal of Urology, vol. 27, no. 1, pp. 117–122, 2009. View at Publisher · View at Google Scholar · View at Scopus
- S. Yang, H. J. Shih, Y. C. Chow, P. S. Tsai, and C. J. Huang, “Hemin induced heme oxygenase-1 over expression involves nuclear factor-E2 related factor-2, nuclear factor-κB and extracellular regulated kinase: an experimental study in a testicular torsion-detorsion rodent model,” Journal of Urology, vol. 179, no. 6, pp. 2456–2463, 2008. View at Publisher · View at Google Scholar · View at Scopus
- S. Payabvash, S. Kiumehr, S. M. Tavangar, and A. R. Dehpour, “Ethyl pyruvate reduces germ cell-specific apoptosis and oxidative stress in rat model of testicular torsion/detorsion,” Journal of Pediatric Surgery, vol. 43, no. 4, pp. 705–712, 2008. View at Publisher · View at Google Scholar · View at Scopus
- G. Gokce, H. Karboga, E. Yildiz, S. Ayan, and Y. Gultekin, “Effect of angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade on apoptotic changes in contralateral testis following unilateral testicular torsion,” International Urology and Nephrology, vol. 40, no. 4, pp. 989–995, 2008. View at Publisher · View at Google Scholar · View at Scopus
- Y. Clermont, “Kinetics of spermatogenesis in mammals: seminiferous epithelium cycle and spermatogonial renewal,” Physiological Reviews, vol. 52, no. 1, pp. 198–236, 1972. View at Scopus
- M. J. Free, G. A. Schluntz, and R. A. Jaffe, “Respiratory gas tensions in tissues and fluids of the male rat reproductive tract,” Biology of Reproduction, vol. 14, no. 4, pp. 481–488, 1976. View at Scopus
- U. R. Jewell, I. Kvietikova, A. Scheid, C. Bauer, R. H. Wenger, and M. Gassmann, “Induction of HIF-1alpha in response to hypoxia is instantaneous,” The FASEB Journal, vol. 15, no. 7, pp. 1312–1314, 2001. View at Scopus
- J. D. Powell, R. Elshtein, D. J. Forest, and M. A. Palladino, “Stimulation of hypoxia-inducible factor-1 alpha (HIF-1α) protein in the adult rat testis following ischemic injury occurs without an increase in HIF-1α messenger RNA expression,” Biology of Reproduction, vol. 67, no. 3, pp. 995–1002, 2002. View at Publisher · View at Google Scholar · View at Scopus
- M. A. Palladino, J. D. Powell, N. Korah, and L. Hermo, “Expression and localization of hypoxia-inducible factor-1 subunits in the adult rat epididymis,” Biology of Reproduction, vol. 70, no. 4, pp. 1121–1130, 2004. View at Publisher · View at Google Scholar · View at Scopus
- H. H. Marti, D. M. Katschinski, K. F. Wagner, L. Schäffer, B. Stier, and R. H. Wenger, “Isoform-specific expression of hypoxia-inducible factor-1α during the late stages of mouse spermiogenesis,” Molecular Endocrinology, vol. 16, no. 2, pp. 234–243, 2002. View at Publisher · View at Google Scholar · View at Scopus
- A. Nalbandian, L. Dettin, M. Dym, and N. Ravindranath, “Expression of vascular endothelial growth factor receptors during male germ cell differentiation in the mouse,” Biology of Reproduction, vol. 69, no. 3, pp. 985–994, 2003. View at Publisher · View at Google Scholar · View at Scopus
- S. Ergün, N. Kiliç, W. Fiedler, and A. K. Mukhopadhyay, “Vascular endothelial growth factor and its receptors in normal human testicular tissue,” Molecular and Cellular Endocrinology, vol. 131, no. 1, pp. 9–20, 1997. View at Publisher · View at Google Scholar · View at Scopus
- G. S. Marchand, N. Noiseux, J. F. Tanguay, and M. G. Sirois, “Blockade of in vivo VEGF-mediated angiogenesis by antisense gene therapy role of Flk-1 and Flt-1 receptors,” American Journal of Physiology, vol. 282, no. 1, pp. H194–H204, 2002. View at Scopus
- G. S. Hwang, S. W. Wang, W. M. Tseng, C. H. Yu, and P. S. Wang, “Effect of hypoxia on the release of vascular endothelial growth factor and testosterone in mouse TM3 Leydig cells,” American Journal of Physiology, vol. 292, no. 6, pp. E1763–E1769, 2007. View at Publisher · View at Google Scholar · View at Scopus
- G.-S. Hwang, S.-T. Chen, T.-J. Chen, and S.-W. Wang, “Effects of hypoxia on testosterone release in rat Leydig cells,” American Journal of Physiology, vol. 297, no. 5, pp. E1039–E1045, 2009. View at Publisher · View at Google Scholar · View at Scopus
- E. Madrid, Effect of normobaric hypoxia on the testis: vascularization, proliferation and steroidogenesis: a murine model [Ph.D. thesis], Universidad de Granada, 2011, https://www.educacion.gob.es/teseo/.
- E. M. Madrid, J. G. Reyes, P. V. Crespo, J. M. Hernández García, S. San Martín, and M. Parraga, “Effect of normobaric hypoxia on the testis in a murine model,” Andrología. In press. View at Publisher · View at Google Scholar
- A. Benso, F. Broglio, G. Aimaretti et al., “Endocrine and metabolic responses to extreme altitude and physical exercise in climbers,” European Journal of Endocrinology, vol. 157, no. 6, pp. 733–740, 2007. View at Publisher · View at Google Scholar · View at Scopus
- P. Boksa and Y. Zhang, “Global birth hypoxia increases the neonatal testosterone surge in the rat,” Neuroendocrinology, vol. 88, no. 4, pp. 266–275, 2008. View at Publisher · View at Google Scholar · View at Scopus
- G. F. Gonzales, “Hemoglobin and testosterone: importance on high altitude acclimatization and adaptation,” Revista Peruana de Medicina de Experimental y Salud Publica, vol. 28, no. 1, pp. 92–100, 2011. View at Publisher · View at Google Scholar · View at Scopus
- C. E. Costarella, J. N. Stallone, G. W. Rutecki, and F. C. Whittier, “Testosterone causes direct relaxation of rat thoracic aorta,” Journal of Pharmacology and Experimental Therapeutics, vol. 277, no. 1, pp. 34–39, 1996. View at Scopus
- H. Honda, T. Unemoto, and H. Kogo, “Different mechanisms for testosterone-induced relaxation of aorta between normotensive and spontaneously hypertensive rats,” Hypertension, vol. 34, no. 6, pp. 1232–1236, 1999. View at Scopus
- C. M. Webb, D. L. Adamson, D. De Zeigler, and P. Collins, “Effect of acute testosterone on myocardial ischemia in men with coronary artery disease,” American Journal of Cardiology, vol. 83, no. 3, pp. 437–439, 1999. View at Publisher · View at Google Scholar · View at Scopus
- G. F. Gonzales, V. Tapia, M. Gasco, J. Rubio, and C. Gonzales-Castañeda, “High serum zinc and serum testosterone levels were associated with excessive erythrocytosis in men at high altitudes,” Endocrine, vol. 40, no. 3, pp. 472–480, 2011. View at Publisher · View at Google Scholar · View at Scopus
- N. Bassil, S. Alkaade, and J. E. Morley, “The benefits and risks of testosterone replacement therapy: a review,” Therapeutics and Clinical Risk Management, vol. 5, no. 1, pp. 427–448, 2009. View at Scopus
- A. D. Coviello, B. Kaplan, K. M. Lakshman, T. Chen, A. B. Singh, and S. Bhasin, “Effects of graded doses of testosterone on erythropoiesis in healthy young and older men,” Journal of Clinical Endocrinology and Metabolism, vol. 93, no. 3, pp. 914–919, 2008. View at Publisher · View at Google Scholar · View at Scopus
- L. Huicho, G. Xing, C. Qualls et al., “Abnormal energy regulation in early life: childhood gene expression may predict subsequent chronic mountain sickness,” BMC Pediatrics, vol. 8, article 47, 2008. View at Publisher · View at Google Scholar · View at Scopus
- F. León-Velarde and O. Mejía, “Gene expression in chronic high altitude diseases,” High Altitude Medicine and Biology, vol. 9, no. 2, pp. 130–139, 2008. View at Publisher · View at Google Scholar · View at Scopus
- M. Cikutovic, N. Fuentes, and E. Bustos-Obregón, “Effect of intermittent hypoxia on the reproduction of rats exposed to high altitude in the Chilean Altiplano,” High Altitude Medicine and Biology, vol. 10, no. 4, pp. 357–363, 2009. View at Publisher · View at Google Scholar · View at Scopus
- D. K. Saxena, “Effect of hypoxia by intermittent altitude exposure on semen characteristics and testicular morphology of male rhesus monkeys,” International Journal of Biometeorology, vol. 38, no. 3, pp. 137–140, 1995. View at Publisher · View at Google Scholar · View at Scopus
- S. Amaral, P. J. Oliveira, and J. Ramalho-Santos, “Diabetes and the impairment of reproductive function: possible role of mitochondria and reactive oxygen species,” Current Diabetes Reviews, vol. 4, no. 1, pp. 46–54, 2008. View at Publisher · View at Google Scholar · View at Scopus
- P. Y. Liu, I. D. Caterson, R. R. Grunstein, and D. J. Handelsman, “Androgens, obesity, and sleep-disordered breathing in men,” Endocrinology and Metabolism Clinics of North America, vol. 36, no. 2, pp. 349–363, 2007. View at Publisher · View at Google Scholar · View at Scopus
- N. S. Chandel, E. Maltepe, E. Goldwasser, C. E. Mathieu, M. C. Simon, and P. T. Schumacker, “Mitochondrial reactive oxygen species trigger hypoxia-induced transcription,” Proceedings of the National Academy of Sciences of the United States of America, vol. 95, no. 20, pp. 11715–11720, 1998. View at Publisher · View at Google Scholar · View at Scopus
- R. D. Guzy, B. Hoyos, E. Robin et al., “Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing,” Cell Metabolism, vol. 1, no. 6, pp. 401–408, 2005. View at Publisher · View at Google Scholar · View at Scopus
- K. D. Mansfield, R. D. Guzy, Y. Pan et al., “Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-α activation,” Cell Metabolism, vol. 1, no. 6, pp. 393–399, 2005. View at Publisher · View at Google Scholar · View at Scopus
- R. D. Guzy and P. T. Schumacker, “Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia,” Experimental Physiology, vol. 91, no. 5, pp. 807–819, 2006. View at Publisher · View at Google Scholar · View at Scopus
- T. P. Cash, Y. Pan, and M. C. Simon, “Reactive oxygen species and cellular oxygen sensing,” Free Radical Biology and Medicine, vol. 43, no. 9, pp. 1219–1225, 2007. View at Publisher · View at Google Scholar · View at Scopus
- F. Bodea, A. Bocea, and N. Decea, “L-carnitine decreases oxidative stress induced by experimental hypobaric hypoxia,” Pediatric Endocrinology, Diabetes and Metabolism, vol. 16, no. 2, pp. 78–81, 2010. View at Scopus
- R. Dirmeier, K. M. O'Brien, M. Engle, A. Dodd, E. Spears, and R. O. Poyton, “Exposure of yeast cells to anoxia induces transient oxidative stress: implications for the induction of hypoxic genes,” Journal of Biological Chemistry, vol. 277, no. 38, pp. 34773–34784, 2002. View at Publisher · View at Google Scholar · View at Scopus
- A. Morgentaler, B. C. Stahl, and Y. Yin, “Testis and temperature: an historical, clinical, and research perspective,” Journal of Andrology, vol. 20, no. 2, pp. 189–195, 1999. View at Scopus
- Y. Li, Q. Zhou, R. Hively, L. Yang, C. Small, and M. D. Griswold, “Differential gene expression in the testes of different murine strains under normal and hyperthermic conditions,” Journal of Andrology, vol. 30, no. 3, pp. 325–337, 2009. View at Publisher · View at Google Scholar · View at Scopus
- K. M. Cammack, E. Antoniou, L. Hearne, and W. R. Lamberson, “Testicular gene expression in male mice divergent for fertility after heat stress,” Theriogenology, vol. 71, no. 4, pp. 651–661, 2009. View at Publisher · View at Google Scholar · View at Scopus
- H. Zhu, Y. Cui, J. Xie et al., “Proteomic analysis of testis biopsies in men treated with transient scrotal hyperthermia reveals the potential targets for contraceptive development,” Proteomics, vol. 10, no. 19, pp. 3480–3493, 2010. View at Publisher · View at Google Scholar · View at Scopus
- Y. H. Lue, A. P. Sinha Hikim, R. S. Swerdloff et al., “Single exposure to heat induces stage-specific germ cell apoptosis in rats: role of intratesticular testosterone on stage specificity,” Endocrinology, vol. 140, no. 4, pp. 1709–1717, 1999. View at Scopus
- Y. Zhang, X. Yang, H. Cao, Z. Chen, Y. Du, and W. Kong, “Heat stress induces Cdc2 protein decrease prior to mouse spermatogenic cell apoptosis,” Acta Histochemica, vol. 110, no. 4, pp. 276–284, 2008. View at Publisher · View at Google Scholar · View at Scopus
- G. S. Waites and B. P. Setchell, “Physiology of mammalian testis,” in Marshall's Physiology of Reproduction, G. Lamming, Ed., pp. 1–106, Churchill Livingstone, New York, NY, USA, 1990.
- Y. Yin, B. C. Stahl, W. C. DeWolf, and A. Morgentaler, “Heat-induced testicular apoptosis occurs independently of hormonal depletion,” Apoptosis, vol. 3, no. 4, pp. 281–287, 1998. View at Scopus
- Y. H. Lue, B. L. Lasley, L. S. Laughlin et al., “Mild testicular hyperthermia induces profound transitional spermatogenic suppression through increased germ cell apoptosis in adult Cynomolgus monkeys (Macaca fascicularis),” Journal of Andrology, vol. 23, no. 6, pp. 799–805, 2002. View at Scopus
- A. P. Sinha Hikim, Y. Lue, C. M. Yamamoto et al., “Key apoptotic pathways for heat-induced programmed germ cell death in the testis,” Endocrinology, vol. 144, no. 7, pp. 3167–3175, 2003. View at Publisher · View at Google Scholar · View at Scopus
- S. Matsuki, Y. Iuchi, Y. Ikeda, I. Sasagawa, Y. Tomita, and J. Fujii, “Suppression of cytochrome c release and apoptosis in testes with heat stress by minocycline,” Biochemical and Biophysical Research Communications, vol. 312, no. 3, pp. 843–849, 2003. View at Publisher · View at Google Scholar · View at Scopus
- Y. Vera, M. Diaz-Romero, S. Rodriguez et al., “Mitochondria-dependent pathway is involved in heat-induced male germ cell death: lessons from mutant mice,” Biology of Reproduction, vol. 70, no. 5, pp. 1534–1540, 2004. View at Publisher · View at Google Scholar · View at Scopus
- Y. Jia, J. Castellanos, C. Wang et al., “Mitogen-activated protein kinase signaling in male germ cell apoptosis in the rat,” Biology of Reproduction, vol. 80, no. 4, pp. 771–780, 2009. View at Publisher · View at Google Scholar · View at Scopus
- Y. Vera, S. Rodriguez, M. Castanares et al., “Functional role of caspases in heat-induced testicular germ cell apoptosis,” Biology of Reproduction, vol. 72, no. 3, pp. 516–522, 2005. View at Publisher · View at Google Scholar · View at Scopus
- K. Makker, A. Agarwal, and R. Sharma, “Oxidative stress & male infertility,” Indian Journal of Medical Research, vol. 129, no. 4, pp. 357–367, 2009. View at Scopus
- S. C. Sikka, “Relative impact of oxidative stress on male reproductive function,” Current Medicinal Chemistry, vol. 8, no. 7, pp. 851–862, 2001. View at Scopus
- A. Kumagai, H. Kodama, J. Kumagai et al., “Xanthine oxidase inhibitors suppress testicular germ cell apoptosis induced by experimental cryptorchidism,” Molecular Human Reproduction, vol. 8, no. 2, pp. 118–123, 2002. View at Scopus
- B. G. Hill, B. P. Dranka, S. M. Bailey, J. R. Lancaster, and V. M. Darley-Usmar, “What part of NO don't you understand? Some answers to the cardinal questions in nitric oxide biology,” Journal of Biological Chemistry, vol. 285, no. 26, pp. 19699–19704, 2010. View at Publisher · View at Google Scholar · View at Scopus
- P. Pacher, J. S. Beckman, and L. Liaudet, “Nitric oxide and peroxynitrite in health and disease,” Physiological Reviews, vol. 87, no. 1, pp. 315–424, 2007. View at Publisher · View at Google Scholar · View at Scopus
- P. Calcerrada, G. Peluffo, and R. Radi, “Nitric oxide-derived oxidants with a focus on peroxynitrite: molecular targets, cellular responses and therapeutic implications,” Current Pharmaceutical Design, vol. 17, no. 35, pp. 3905–3932, 2011. View at Scopus
- J. Guo, Y. Jia, S. X. Tao et al., “Expression of nitric oxide synthase during germ cell apoptosis in testis of cynomolgus monkey after testosterone and heat treatment,” Journal of Andrology, vol. 30, no. 2, pp. 190–199, 2009. View at Publisher · View at Google Scholar · View at Scopus
- A. Nakai, M. Suzuki, and M. Tanabe, “Arrest of spermatogenesis in mice expressing an active heat shock transcription factor 1,” EMBO Journal, vol. 19, no. 7, pp. 1545–1554, 2000. View at Scopus
- L. Somwaru, S. Li, L. Doglio, E. Goldberg, and B. R. Zirkin, “Heat-induced apoptosis of mouse meiotic cells is suppressed by ectopic expression of testis-specific calpastatin,” Journal of Andrology, vol. 25, no. 4, pp. 506–513, 2004. View at Scopus
- M. Chen, J. X. Yuan, Y. Q. Shi et al., “Effect of 43°C treatment on expression of heat shock proteins 105, 70 and 60 in cultured monkey Sertoli cells,” Asian Journal of Andrology, vol. 10, no. 3, pp. 474–485, 2008. View at Publisher · View at Google Scholar · View at Scopus
- K. De Gendt, J. V. Swinnen, P. T. K. Saunders et al., “A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis,” Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 5, pp. 1327–1332, 2004. View at Publisher · View at Google Scholar · View at Scopus
- C. Chang, Y. T. Chen, S. D. Yeh et al., “Infertility with defective spermatogenesis and hypotestosteronemia in male mice lacking the androgen receptor in Sertoli cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 18, pp. 6876–6881, 2004. View at Publisher · View at Google Scholar · View at Scopus
- E. Herrera, K. Salas, N. Lagos, D. J. Benos, and J. G. Reyes, “Energy metabolism and its linkage to intracellular Ca2+ and pH regulation in rat spermatogenic cells,” Biology of the Cell, vol. 92, no. 6, pp. 429–440, 2000. View at Publisher · View at Google Scholar · View at Scopus
- J. G. Reyes, N. Osses, M. Knox, A. Darszon, and C. L. Treviño, “Glucose and lactate regulate maitotoxin-activated Ca2+ entry in spermatogenic cells: the role of intracellular [Ca2+],” FEBS Letters, vol. 584, no. 14, pp. 3111–3115, 2010. View at Publisher · View at Google Scholar · View at Scopus
- C. Lizama, I. Alfaro, J. G. Reyes, and R. D. Moreno, “Up-regulation of CD95 (Apo-1/Fas) is associated with spermatocyte apoptosis during the first round of spermatogenesis in the rat,” Apoptosis, vol. 12, no. 3, pp. 499–512, 2007. View at Publisher · View at Google Scholar · View at Scopus
- S. Wang, P. Song, and M.-H. Zou, “AMP-activated protein kinase, stress responses and cardiovascular diseases,” Clinical Science, vol. 122, no. 12, pp. 555–573, 2012. View at Publisher · View at Google Scholar · View at Scopus
- R. A. Zager, D. S. Conrad, and K. Burkhart, “Phospholipase A2: a potentially important determinant of adenosine triphosphate levels during hypoxic-reoxygenation tubular injury,” Journal of the American Society of Nephrology, vol. 7, no. 11, pp. 2327–2339, 1996. View at Scopus
- E. Tanaka, S. Niiyama, S. Sato, A. Yamada, and H. Higashi, “Arachidonic acid metabolites contribute to the irreversible depolarization induced by in vitro ischemia,” Journal of Neurophysiology, vol. 90, no. 5, pp. 3213–3223, 2003. View at Publisher · View at Google Scholar · View at Scopus
- I. H. Lambert and S. F. Pedersen, “Multiple PLA2 isoforms regulate taurine release in NIH3T3 mouse fibroblasts,” Advances in Experimental Medicine and Biology, vol. 583, pp. 99–108, 2006. View at Publisher · View at Google Scholar · View at Scopus
- E. A. Jannini, S. Ulisse, S. Cecconi et al., “Follicle-stimulating hormone-induced phospholipase A2 activity and eicosanoid generation in rat sertoli cells,” Biology of Reproduction, vol. 51, no. 1, pp. 140–145, 1994. View at Publisher · View at Google Scholar · View at Scopus
- J. Lee, J. H. Richburg, S. C. Younking, and K. Boekelheide, “The Fas system is a key regulator of germ cell apoptosis in the testis,” Endocrinology, vol. 138, no. 5, pp. 2081–2088, 1997. View at Scopus
- S. Ulisse, B. Cinque, G. Silvano et al., “Erk-dependent cytosolic phospholipase A2 activity is induced by CD95 ligand cross-linking in the mouse derived Sertoli cell line TM4 and is required to trigger apoptosis in CD95 bearing cells,” Cell Death and Differentiation, vol. 7, no. 10, pp. 916–924, 2000. View at Scopus
- Y. Gat, M. Gornish, and S. Joshua, “Erect posture of humans leads to male infertility, BPH and prostate cancer,” Andrologia, vol. 44, no. 3, pp. 145–146, 2012. View at Publisher · View at Google Scholar · View at Scopus
- Y. Gat, M. Gornish, U. Navon, J. Chakraborty, G. N. Bachar, and I. Ben-Shlomo, “Right varicocele and hypoxia, crucial factors in male infertility: fluid mechanics analysis of the impaired testicular drainage system,” Reproductive BioMedicine Online, vol. 13, no. 4, article 2380, pp. 510–515, 2006. View at Scopus
- M. A. Will, J. Swain, M. Fode, J. Sonksen, G. M. Christman, and D. Ohl, “The great debate: varicocele treatment and impact on fertility,” Fertility and Sterility, vol. 95, no. 3, pp. 841–852, 2011. View at Publisher · View at Google Scholar · View at Scopus
- K. Shiraishi, H. Matsuyama, and H. Takihara, “Pathophysiology of varicocele in male infertility in the era of assisted reproductive technology,” International Journal of Urology, vol. 19, no. 6, pp. 538–550, 2012. View at Publisher · View at Google Scholar · View at Scopus
- F. Kilinç, F. Kayaselcuk, C. Aygun, S. Guvel, T. Egilmez, and H. Ozkardes, “Experimental varicocele induces hypoxia inducible factor-1α, vascular endothelial growth factor expression and angiogenesis in the rat testis,” Journal of Urology, vol. 172, no. 3, pp. 1188–1191, 2004. View at Publisher · View at Google Scholar · View at Scopus
- J. S. Paick, K. Park, S. W. Kim et al., “Increased expression of hypoxia-inducible factor-1α and connective tissue growth factor accompanied by fibrosis in the rat testis of varicocele,” Actas Urologicas Espanolas, vol. 36, no. 5, pp. 282–288, 2012. View at Publisher · View at Google Scholar · View at Scopus
- K. Shiraishi and K. Naito, “Involvement of vascular endothelial growth factor on spermatogenesis in testis with varicocele,” Fertility and Sterility, vol. 90, no. 4, pp. 1313–1316, 2008. View at Publisher · View at Google Scholar · View at Scopus
- A. Merla, A. Ledda, L. Di Donato, S. Di Luzio, and G. L. Romani, “Use of infrared functional imaging to detect impaired thermoregulatory control in men with asymptomatic varicocele,” Fertility and Sterility, vol. 78, no. 1, pp. 199–200, 2002. View at Publisher · View at Google Scholar · View at Scopus
- E. J. Wright, G. P. H. Young, and M. Goldstein, “Reduction in testicular temperature after varicocelectomy in infertile men,” Urology, vol. 50, no. 2, pp. 257–259, 1997. View at Publisher · View at Google Scholar · View at Scopus
- T. Mostafa, T. H. Anis, A. El-Nashar, H. Imam, and I. A. Othman, “Varicocelectomy reduces reactive oxygen species levels and increases antioxidant activity of seminal plasma from infertile men with varicocele,” International Journal of Andrology, vol. 24, no. 5, pp. 261–265, 2001. View at Publisher · View at Google Scholar · View at Scopus
- R. Dada, M. B. Shamsi, S. Venkatesh, N. P. Gupta, and R. Kumar, “Attenuation of oxidative stress & DNA damage in varicocelectomy: implications in infertility management,” Indian Journal of Medical Research, vol. 132, no. 12, pp. 728–730, 2010. View at Scopus
- K. Shiraishi, H. Takihara, and H. Matsuyama, “Elevated scrotal temperature, but not varicocele grade, reflects testicular oxidative stress-mediated apoptosis,” World Journal of Urology, vol. 28, no. 3, pp. 359–364, 2010. View at Publisher · View at Google Scholar · View at Scopus
- A. Agarwal, S. Prabakaran, and S. S. S. R. Allamaneni, “Relationship between oxidative stress, varicocele and infertility: a meta-analysis,” Reproductive BioMedicine Online, vol. 12, no. 5, article 2200, pp. 630–633, 2006. View at Scopus
- A. Agarwal, K. Makker, and R. Sharma, “Clinical relevance of oxidative stress in male factor infertility: an update,” American Journal of Reproductive Immunology, vol. 59, no. 1, pp. 2–11, 2008. View at Publisher · View at Google Scholar · View at Scopus
- C. J. Yoon, H. J. Park, and N. C. Park, “Reactive oxygen species in the internal spermatic and brachial veins of patients with varicocele-induced infertility,” Korean Journal of Urology, vol. 51, no. 5, pp. 348–353, 2010. View at Publisher · View at Google Scholar · View at Scopus
- J. J. Lysiak, Q. A. T. Nguyen, and T. T. Turner, “Peptide and nonpeptide reactive oxygen scavengers provide partial rescue of the testis after torsion,” Journal of Andrology, vol. 23, no. 3, pp. 400–409, 2002. View at Scopus
- S. S. R. Allamaneni, C. K. Naughton, R. K. Sharma, A. J. Thomas, and A. Agarwal, “Increased seminal reactive oxygen species levels in patients with varicoceles correlate with varicocele grade but not with testis size,” Fertility and Sterility, vol. 82, no. 6, pp. 1684–1686, 2004. View at Publisher · View at Google Scholar · View at Scopus
- T. Mostafa, T. Anis, A. El Nashar, H. Imam, and I. Osman, “Seminal plasma reactive oxygen species-antioxidants relationship with varicocele grade,” Andrologia, vol. 44, no. 1, pp. 66–69, 2012. View at Publisher · View at Google Scholar · View at Scopus
- U. O. Zorba, O. M. Sanli, M. Tezer, F. Erdemir, S. Shavakhabov, and A. Kadioglu, “Effect of infertility duration on postvaricocelectomy sperm counts and pregnancy rates,” Urology, vol. 73, no. 4, pp. 767–771, 2009. View at Publisher · View at Google Scholar · View at Scopus
- I. T. Köksal, T. Erdoǧru, H. Gülkesen et al., “The potential role of inducible nitric oxide synthase (iNOS) activity in the testicular dysfunction associated with varicocele: an experimental study,” International Urology and Nephrology, vol. 36, no. 1, pp. 67–72, 2004. View at Publisher · View at Google Scholar · View at Scopus
- Z. Sahin, C. Celik-Ozenci, G. Akkoyunlu et al., “Increased expression of interleukin-1α and interleukin-1β is associated with experimental varicocele,” Fertility and Sterility, vol. 85, supplement 1, pp. 1265–1275, 2006. View at Publisher · View at Google Scholar · View at Scopus
- A. Fazlioglu, I. Yilmaz, O. Mete, et al., “The effect of varicocele repair on experimental varicocele-induced testicular germ cell apoptosis,” Journal of Andrology, vol. 29, no. 1, pp. 29–34, 2008. View at Publisher · View at Google Scholar · View at Scopus
- S. Ueda, H. Masutani, H. Nakamura, T. Tanaka, M. Ueno, and J. Yodoi, “Redox control of cell death,” Antioxidants and Redox Signaling, vol. 4, no. 3, pp. 405–414, 2002. View at Scopus
- J. Matsukawa, A. Matsuzawa, K. Takeda, and H. Ichijo, “The ASK1-MAP kinase cascades in mammalian stress response,” Journal of Biochemistry, vol. 136, no. 3, pp. 261–265, 2004. View at Publisher · View at Google Scholar · View at Scopus
- C. Lizama, C. F. Lagos, R. Lagos-Cabré et al., “Calpain inhibitors prevent p38 MAPK activation and germ cell apoptosis after heat stress in pubertal rat testes,” Journal of Cellular Physiology, vol. 221, no. 2, pp. 296–305, 2009. View at Publisher · View at Google Scholar · View at Scopus
- K. Shiraishi and K. Naito, “Effects of 4-hydroxy-2-nonenal, a marker of oxidative stress, on spermatogenesis and expression of p53 protein in male infertility,” Journal of Urology, vol. 178, no. 3, pp. 1012–1017, 2007. View at Publisher · View at Google Scholar · View at Scopus
- J. D. Lee, T. H. Lee, W. H. Cheng, and S. Y. Jeng, “Involved intrinsic apoptotic pathway of testicular tissues in varicocele-induced rats,” World Journal of Urology, vol. 27, no. 4, pp. 527–532, 2009. View at Publisher · View at Google Scholar · View at Scopus
- F. W. Chang, G. H. Sun, Y. Y. Cheng, I. C. Chen, H. H. Chien, and G. J. Wu, “Effects of varicocele upon the expression of apoptosis-related proteins,” Andrologia, vol. 42, no. 4, pp. 225–230, 2010. View at Publisher · View at Google Scholar · View at Scopus
- I. Y. Chang, J. H. Kim, K. H. Park, and S. P. Yoon, “Experimental varicocele induces p53-dependent germ cell apoptosis through activation of γ-H2AX,” Urologia Internationalis, vol. 85, no. 2, pp. 216–220, 2010. View at Publisher · View at Google Scholar · View at Scopus
- S. J. Workman and B. A. Kogan, “Old and new aspects of testicular torsion,” Seminars in Urology, vol. 6, no. 2, pp. 146–157, 1988. View at Scopus
- J. Cubillos, J. S. Palmer, S. C. Friedman, J. Freyle, F. C. Lowe, and L. S. Palmer, “Familial testicular torsion,” Journal of Urology, vol. 185, no. 6, pp. 2469–2472, 2011. View at Publisher · View at Google Scholar · View at Scopus
- J. J. Lysiak, Q. A. T. Nguyen, and T. T. Turner, “Fluctuations in rat testicular interstitial oxygen tensions are linked to testicular vasomotion: persistence after repair of torsion,” Biology of Reproduction, vol. 63, no. 5, pp. 1383–1389, 2000. View at Scopus
- T. T. Turner, H. J. Bang, and J. L. Lysiak, “The molecular pathology of experimental testicular torsion suggests adjunct therapy to surgical repair,” Journal of Urology, vol. 172, no. 6, pp. 2574–2578, 2004. View at Publisher · View at Google Scholar · View at Scopus
- T. T. Turner, H. J. Bang, and J. J. Lysiak, “Experimental testicular torsion: reperfusion blood flow and subsequent testicular venous plasma testosterone concentrations,” Urology, vol. 65, no. 2, pp. 390–394, 2005. View at Publisher · View at Google Scholar · View at Scopus
- E. Ringdahl and L. Teague, “Testicular torsion,” American Family Physician, vol. 74, no. 10, pp. 1739–1746, 2006. View at Scopus
- J. J. Lysiak, S. Zheng, R. Woodson, and T. T. Turner, “Caspase-9-dependent pathway to murine germ cell apoptosis: mediation by oxidative stress, BAX, and caspase 2,” Cell and Tissue Research, vol. 328, no. 2, pp. 411–419, 2007. View at Publisher · View at Google Scholar · View at Scopus
- T. T. Turner and J. L. Lysiak, “Oxidative stress: a common factor in testicular dysfunction,” Journal of Andrology, vol. 29, no. 5, pp. 488–498, 2008. View at Publisher · View at Google Scholar · View at Scopus
- J. J. Lysiak, S. D. Turner, Q. A. T. Nguyen, K. Singbartl, K. Ley, and T. T. Turner, “Essential role of neutrophils in germ cell-specific apoptosis following ischemia/reperfusion injury of the mouse testis,” Biology of Reproduction, vol. 65, no. 3, pp. 718–725, 2001. View at Scopus
- J. J. Lysiak, Q. A. T. Nguyen, J. L. Kirby, and T. T. Turner, “Ischemia-reperfusion of the murine testis stimulates the expression of proinflammatory cytokines and activation of c-jun N-terminal kinase in a pathway to E-selectin expression,” Biology of Reproduction, vol. 69, no. 1, pp. 202–210, 2003. View at Publisher · View at Google Scholar · View at Scopus
- X. Bustamante-Marín, C. Quiroga, S. Lavandero, J. G. Reyes, and R. D. Moreno, “Apoptosis, necrosis and autophagy are influenced by metabolic energy sources in cultured rat spermatocytes,” Apoptosis, vol. 17, no. 6, pp. 539–550, 2012. View at Publisher · View at Google Scholar · View at Scopus
- J. J. Lysiak, S. D. Turner, and T. T. Turner, “Molecular pathway of germ cell apoptosis following ischemia/reperfusion of the rat testis,” Biology of Reproduction, vol. 63, no. 5, pp. 1465–1472, 2000. View at Scopus
- I. Sukhotnik, K. Voskoboinik, M. Lurie, Y. Bejar, A. G. Coran, and J. G. Mogilner, “Involvement of the bax and bcl-2 system in the induction of germ cell apoptosis is correlated with the time of reperfusion after testicular ischemia in a rat model,” Fertility and Sterility, vol. 92, no. 4, pp. 1466–1469, 2009. View at Publisher · View at Google Scholar · View at Scopus
- K. Shiraishi, K. Naito, and K. I. Yoshida, “Inhibition of calpain but not caspase protects the testis against injury after experimental testicular torsion of rat,” Biology of Reproduction, vol. 63, no. 5, pp. 1538–1548, 2000. View at Scopus
- J. J. Lysiak, “The role of tumor necrosis factor-alpha and interleukin-1 in the mammalian testis and their involvement in testicular torsion and autoimmune orchitis,” Reproductive Biology and Endocrinology, vol. 2, article 9, 2004. View at Publisher · View at Google Scholar · View at Scopus
- S. K. De, H. L. Chen, J. L. Pace, J. S. Hunt, P. F. Terranova, and G. C. Enders, “Expression of tumor necrosis factor-α in mouse spermatogenic cells,” Endocrinology, vol. 133, no. 1, pp. 389–396, 1993. View at Publisher · View at Google Scholar · View at Scopus
- R. D. Moreno, P. Urriola-Munoz, and R. Lagos-Cabre, “The emerging role of matrix metalloproteases of the ADAM family in male germ cell apoptosis,” Spermatogenesis, vol. 1, pp. 195–208, 2011.
- C. Lizama, D. Rojas-Benítez, M. Antonelli et al., “TACE/ADAM17 is involved in germ cell apoptosis during rat spermatogenesis,” Reproduction, vol. 140, no. 2, pp. 305–317, 2010. View at Publisher · View at Google Scholar · View at Scopus
- C. Lizama, A. Ludwig, and R. D. Moreno, “Etoposide induces apoptosis and upregulation of TACE/ADAM17 and ADAM10 in an in vitro male germ cell line model,” Biochimica et Biophysica Acta, vol. 1813, no. 1, pp. 120–128, 2011. View at Publisher · View at Google Scholar · View at Scopus
- C. Lizama, D. Rojas-benitez, M. Antonelli, A. Ludwig, and R. D. Moreno, “Involvement of TACE/ADAM17 and ADAM10 in etoposide-induced apoptosis of germ cells in rat spermatogenesis,” Journal of Cellular Physiology, vol. 227, no. 2, pp. 829–838, 2012. View at Publisher · View at Google Scholar · View at Scopus
- W. Eggert-Kruse, I. Kiefer, C. Beck, T. Demirakca, and T. Strowitzki, “Role for tumor necrosis factor alpha (TNF-α) and interleukin 1-beta (IL-1β) determination in seminal plasma during infertility investigation,” Fertility and Sterility, vol. 87, no. 4, pp. 810–823, 2007. View at Publisher · View at Google Scholar · View at Scopus
- S. Seshadri, M. Bates, G. Vince, and D. I. L. Jones, “The role of cytokine expression in different subgroups of subfertile men,” American Journal of Reproductive Immunology, vol. 62, no. 5, pp. 275–282, 2009. View at Publisher · View at Google Scholar · View at Scopus
- E. Martínez-Prado and M. I. Camejo Bermúdez, “Expression of IL-6, IL-8, TNF-α, IL-10, HSP-60, anti-HSP-60 antibodies, and anti-sperm antibodies, in semen of men with leukocytes and/or bacteria,” American Journal of Reproductive Immunology, vol. 63, no. 3, pp. 233–243, 2010. View at Publisher · View at Google Scholar · View at Scopus
- H. V. Edwards, J. D. Scott, and G. S. Baillie, “PKA phosphorylation of the small heat-shock protein Hsp20 enhances its cardioprotective effects,” Biochemical Society Transactions, vol. 40, no. 1, pp. 210–214, 2012. View at Publisher · View at Google Scholar · View at Scopus
- H. Ji, X.-D. Shen, Y. Zhang et al., “Activation of cyclic adenosine monophosphate-dependent protein kinase a signaling prevents liver ischemia/reperfusion injury in mice,” Liver Transplantation, vol. 18, no. 6, pp. 659–670, 2012. View at Publisher · View at Google Scholar · View at Scopus