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Linked References

1. A. H. Mokdad, J. S. Marks, D. F. Stroup, and J. L. Gerberding, “Actual causes of death in the United States, 2000,” Journal of the American Medical Association, vol. 291, no. 10, pp. 1238–1245, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
2. G. Li, P. M. Keyl, G. S. Smith, and S. P. Baker, “Alcohol and injury severity: reappraisal of the continuing controversy,” Journal of Trauma, vol. 42, no. 3, pp. 562–569, 1997. View at Publisher · View at Google Scholar · View at Scopus
3. J. Rehm, R. Room, K. Graham, M. Monteiro, G. Gmel, and C. T. Sempos, “The relationship of average volume of alcohol consumption and patterns of drinking to burden of disease: an overview,” Addiction, vol. 98, no. 9, pp. 1209–1228, 2003. View at Publisher · View at Google Scholar · View at Scopus
4. F. P. Rivara, G. J. Jurkovich, J. G. Gurney et al., “The magnitude of acute and chronic alcohol abuse in trauma patients,” Archives of Surgery, vol. 128, no. 8, pp. 907–913, 1993. View at Scopus
5. L. M. Gentilello, B. E. Ebel, T. M. Wickizer, D. S. Salkever, and F. P. Rivara, “Alcohol interventions for trauma patients treated in emergency departments and hospitals: a cost benefit analysis,” Annals of Surgery, vol. 241, no. 4, pp. 541–550, 2005. View at Publisher · View at Google Scholar · View at Scopus
6. J. A. London and F. D. Battistella, “Testing for substance use in trauma patients: are we doing enough?” Archives of Surgery, vol. 142, no. 7, pp. 633–638, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
7. D. M. Boé, S. Nelson, P. Zhang, L. Quinton, and G. J. Bagby, “Alcohol-induced suppression of lung chemokine production and the host defense response to Streptococcus pneumoniae,” Alcoholism: Clinical and Experimental Research, vol. 27, no. 11, pp. 1838–1845, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
8. D. M. Boé, S. Nelson, P. Zhang, and G. J. Bagby, “Acute ethanol intoxication suppresses lung chemokine production following infection with Streptococcus pneumoniae,” Journal of Infectious Diseases, vol. 184, no. 9, pp. 1134–1142, 2001. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
9. M. Ruiz, S. Ewig, A. Torres et al., “Severe community-acquired pneumonia: risk factors and follow-up epidemiology,” American Journal of Respiratory and Critical Care Medicine, vol. 160, no. 3, pp. 923–929, 1999. View at Scopus
10. K. A. N. Messingham, D. E. Faunce, and E. J. Kovacs, “Alcohol, injury, and cellular immunity,” Alcohol, vol. 28, no. 3, pp. 137–149, 2002. View at Publisher · View at Google Scholar · View at Scopus
11. G. J. Bagby, P. Zhang, D. A. Stoltz, and S. Nelson, “Suppression of the granulocyte colony-stimulating factor response to Escherichia coli challenge by alcohol intoxication,” Alcoholism: Clinical and Experimental Research, vol. 22, no. 8, pp. 1740–1745, 1998. View at Scopus
12. P. Zhang, G. J. Bagby, D. M. Boé et al., “Acute alcohol intoxication suppresses the CXC chemokine response during endotoxemia,” Alcoholism: Clinical and Experimental Research, vol. 26, no. 1, pp. 65–73, 2002. View at Scopus
13. M. C. Cowperthwaite and M. G. Burnett, “Treatment course and outcomes following drug and alcohol-related traumatic injuries,” Journal of Trauma Management and Outcomes, vol. 5, no. 1, article 3, 2011. View at Publisher · View at Google Scholar
14. G. J. Jurkovich, F. P. Rivara, J. G. Gurney et al., “The effect of acute alcohol intoxication and chronic alcohol abuse on outcome from trauma,” Journal of the American Medical Association, vol. 270, no. 1, pp. 51–56, 1993. View at Publisher · View at Google Scholar · View at Scopus
15. B. Relja, C. Höhn, F. Bormann et al., “Acute alcohol intoxication reduces mortality, inflammatory responses and hepatic injury after haemorrhage and resuscitation in vivo,” British Journal of Pharmacology, vol. 165, no. 4, pp. 1188–1199, 2012. View at Publisher · View at Google Scholar
16. S. J. Gluckman and R. R. MacGregor, “Effect of acute alcohol intoxication on granulocyte mobilization and Kinetics,” Blood, vol. 52, no. 3, pp. 551–559, 1978. View at Scopus
17. G. Szabo, S. Chavan, P. Mandrekar, and D. Catalano, “Acute alcohol consumption attenuates interleukin-8 (IL-8) and monocyte chemoattractant peptide-1 (MCP-1) induction in response to ex vivo stimulation,” Journal of Clinical Immunology, vol. 19, no. 1, pp. 67–76, 1999. View at Scopus
18. S. Nelson, G. J. Bagby, B. G. Bainton, and W. R. Summer, “The effects of acute and chronic alcoholism on tumor necrosis factor and the inflammatory response,” Journal of Infectious Diseases, vol. 160, no. 3, pp. 422–429, 1989. View at Scopus
19. H. Tsukamoto and S. C. Lu, “Current concepts in the pathogenesis of alcoholic liver injury,” FASEB Journal, vol. 15, no. 8, pp. 1335–1349, 2001. View at Publisher · View at Google Scholar · View at Scopus
20. J. B. Hoek and J. G. Pastorino, “Cellular signaling mechanisms in alcohol-induced liver damage,” Seminars in Liver Disease, vol. 24, no. 3, pp. 257–272, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
21. A. Cahill, C. C. Cunningham, M. Adachi et al., “Effects of alcohol and oxidative stress on liver pathology: the role of the mitochondrion,” Alcoholism: Clinical and Experimental Research, vol. 26, no. 6, pp. 907–915, 2002. View at Publisher · View at Google Scholar · View at Scopus
22. B. Epe, D. Ballmaier, I. Roussyn, K. Briviba, and H. Sies, “DNA damage by peroxynitrite characterized with DNA repair enzymes,” Nucleic Acids Research, vol. 24, no. 21, pp. 4105–4110, 1996. View at Publisher · View at Google Scholar · View at Scopus
23. R. Radi, A. Cassina, R. Hodara, C. Quijano, and L. Castro, “Peroxynitrite reactions and formation in mitochondria,” Free Radical Biology and Medicine, vol. 33, no. 11, pp. 1451–1464, 2002. View at Publisher · View at Google Scholar · View at Scopus
24. G. J. Yuan, X. R. Zhou, Z. J. Gong, P. Zhang, X. M. Sun, and S. H. Zheng, “Expression and activity of inducible nitric oxide synthase and endothelial nitric oxide synthase correlate with ethanol-induced liver injury,” World Journal of Gastroenterology, vol. 12, no. 15, pp. 2375–2381, 2006. View at Scopus
25. I. Larosche, P. Lettéron, A. Berson et al., “Hepatic mitochondrial DNA depletion after an alcohol binge in mice: probable role of peroxynitrite and modulation by manganese superoxide dismutase,” Journal of Pharmacology and Experimental Therapeutics, vol. 332, no. 3, pp. 886–897, 2010. View at Publisher · View at Google Scholar · View at Scopus
26. P. Wieland and B. H. Lauterburg, “Oxidation of mitochondrial proteins and DNA following administration of ethanol,” Biochemical and Biophysical Research Communications, vol. 213, no. 3, pp. 815–819, 1995. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
27. J. F. Passos, G. Saretzki, and T. Von Zglinicki, “DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?” Nucleic Acids Research, vol. 35, no. 22, pp. 7505–7513, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
28. F. M. Akgür, M. F. Brown, G. B. Zibari et al., “Role of superoxide in hemorrhagic shock-induced P-selectin expression,” American Journal of Physiology, vol. 279, no. 2, pp. H791–H797, 2000. View at Scopus
29. K. J. Davies, “Oxidative stress: the paradox of aerobic life,” Biochemical Society symposium, vol. 61, pp. 1–31, 1995. View at Scopus
30. M. Korenaga, T. Wang, Y. Li et al., “Hepatitis C virus core protein inhibits mitochondrial electron transport and increases reactive oxygen species (ROS) production,” Journal of Biological Chemistry, vol. 280, no. 45, pp. 37481–37488, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
31. H. Jaeschke, “Reactive oxygen and mechanisms of inflammatory liver injury: present concepts,” Journal of Gastroenterology and Hepatology, vol. 26, supplement 1, pp. 173–179, 2011. View at Publisher · View at Google Scholar · View at PubMed
32. F. Hong, W. H. Kim, Z. Tian et al., “Elevated interleukin-6 during ethanol consumption acts as a potential endogenous protective cytokine against ethanol-induced apoptosis in the liver: Involvement of induction of Bcl-2 and Bcl-xL proteins,” Oncogene, vol. 21, no. 1, pp. 32–43, 2002. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
33. L. Mela, “Altered mitochondrial metabolism in circulatory shock,” Advances in Experimental Medicine and Biology, vol. 78, pp. 371–373, 1977. View at Scopus
34. A. E. Baue, R. Durham, and E. Faist, “Systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), multiple organ failure (MOF): are we winning the battle?” Shock, vol. 10, no. 2, pp. 79–89, 1998. View at Scopus
35. F. A. Moore, A. Sauaia, E. E. Moore, J. B. Haenel, J. M. Burch, and D. C. Lezotte, “Postinjury multiple organ failure: a bimodal phenomenon,” Journal of Trauma, vol. 40, no. 4, pp. 501–510, 1996. View at Scopus
36. A. Sauaia, F. A. Moore, E. E. Moore et al., “Epidemiology of trauma deaths: a reassessment,” Journal of Trauma, vol. 38, no. 2, pp. 185–193, 1995. View at Scopus
37. M. M. Treggiari, L. D. Hudson, D. P. Martin, N. S. Weiss, E. Caldwell, and G. Rubenfeld, “Effect of acute lung injury and acute respiratory distress syndrome on outcome in critically ill trauma patients,” Critical Care Medicine, vol. 32, no. 2, pp. 327–331, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
38. B. Relja, E. Töttel, L. Breig et al., “Plant polyphenols attenuate hepatic injury after hemorrhage/resuscitation by inhibition of apoptosis, oxidative stress, and inflammation via NF-kappaB in rats,” European Journal of Nutrition, vol. 51, no. 3, pp. 311–321, 2012. View at Publisher · View at Google Scholar
39. B. Relja, M. Lehnert, K. Seyboth et al., “Simvastatin reduces mortality and hepatic injury after hemorrhage/resuscitation in rats,” Shock, vol. 34, no. 1, pp. 46–54, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
40. B. Relja, B. Schwestka, V. S. Y. Lee et al., “Inhibition of c-jun n-terminal kinase after hemorrhage but before resuscitation mitigates hepatic damage and inflammatory response in male rats,” Shock, vol. 32, no. 5, pp. 509–516, 2009. View at Publisher · View at Google Scholar · View at Scopus
41. D. A. Partrick, F. A. Moore, E. E. Moore, C. C. Barnett, and C. C. Silliman, “Neutrophil priming and activation in the pathogenesis of postinjury multiple organ failure,” New Horizons, vol. 4, no. 2, pp. 194–210, 1996. View at Scopus
42. H. Redl, H. Gasser, G. Schlag, and I. Marzi, “Involvement of oxygen radicals in shock related cell injury,” British Medical Bulletin, vol. 49, no. 3, pp. 556–565, 1993. View at Scopus
43. Z. H. Meng, K. Dyer, T. R. Billiar, and D. J. Tweardy, “Essential role for IL-6 in postresuscitation inflammation in hemorrhagic shock,” American Journal of Physiology, vol. 280, no. 2, pp. C343–C351, 2001. View at Scopus
44. M. Lehnert, T. Uehara, B. U. Bradford et al., “Lipopolysaccharide-binding protein modulates hepatic damage and the inflammatory response after hemorrhagic shock and resuscitation,” American Journal of Physiology, vol. 291, no. 3, pp. G456–G463, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
45. Z. Zhong, M. Froh, H. D. Connor et al., “Prevention of hepatic ischemia-reperfusion injury by green tea extract,” American Journal of Physiology, vol. 283, no. 4, pp. G957–G964, 2002. View at Scopus
46. J. L. Farber, “Mechanisms of cell injury by activated oxygen species,” Environmental Health Perspectives, vol. 102, no. 10, pp. 17–24, 1994. View at Scopus
47. K. L. Zambell, H. Phelan, C. V. Stouwe, P. Zhang, J. E. Shellito, and P. E. Molina, “Acute alcohol intoxication during hemorrhagic shock: impact on host defense from infection,” Alcoholism: Clinical and Experimental Research, vol. 28, no. 4, pp. 635–642, 2004. View at Publisher · View at Google Scholar · View at Scopus
48. P. Greiffenstein, K. W. Mathis, C. V. Stouwe, and P. E. Molina, “Alcohol binge before trauma/hemorrhage impairs integrity of host defense mechanisms during recovery,” Alcoholism: Clinical and Experimental Research, vol. 31, no. 4, pp. 704–715, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
49. H. Phelan, P. Stahls, J. Hunt, G. J. Bagby, and P. E. Molina, “Impact of alcohol intoxication on hemodynamic, metabolic, and cytokine responses to hemorrhagic shock,” Journal of Trauma, vol. 52, no. 4, pp. 675–682, 2002. View at Scopus
50. M. Yokouchi, N. Hiramatsu, K. Hayakawa et al., “Involvement of selective reactive oxygen species upstream of proapoptotic branches of unfolded protein response,” Journal of Biological Chemistry, vol. 283, no. 7, pp. 4252–4260, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
51. A. Kasdallah-Grissa, B. Mornagui, E. Aouani et al., “Resveratrol, a red wine polyphenol, attenuates ethanol-induced oxidative stress in rat liver,” Life Sciences, vol. 80, no. 11, pp. 1033–1039, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
52. M. Jurczuk, M. M. Brzóska, J. Moniuszko-Jakoniuk, M. Gałazyn-Sidorczuk, and E. Kulikowska-Karpińska, “Antioxidant enzymes activity and lipid peroxidation in liver and kidney of rats exposed to cadmium and ethanol,” Food and Chemical Toxicology, vol. 42, no. 3, pp. 429–438, 2004. View at Publisher · View at Google Scholar · View at PubMed
53. K. Husain, J. Mejia, J. Lalla, and S. Kazim, “Dose response of alcohol-induced changes in BP, nitric oxide and antioxidants in rat plasma,” Pharmacological Research, vol. 51, no. 4, pp. 337–343, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
54. R. Polavarapu, D. R. Spitz, J. E. Sim et al., “Increased lipid peroxidation and impaired antioxidant enzyme function is associated with pathological liver injury in experimental alcoholic liver disease in rats fed diets high in corn oil and fish oil,” Hepatology, vol. 27, no. 5, pp. 1317–1323, 1998. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
55. C. S. Lieber, “Alcohol and the liver: metabolism of alcohol and its role in hepatic and extrahepatic diseases,” Mount Sinai Journal of Medicine, vol. 67, no. 1, pp. 84–94, 2000. View at Scopus
56. S. W. French, K. Wong, L. Jui, E. Albano, A. L. Hagbjork, and M. Ingelman-Sundberg, “Effect of ethanol on cytochrome P450 2E1 (CYP2E1), lipid peroxidation, and serum protein adduct formation in relation to liver pathology pathogenesis,” Experimental and Molecular Pathology, vol. 58, no. 1, pp. 61–75, 1993. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
57. J. Kaur, S. Shalini, and M. P. Bansal, “Influence of vitamin e on alcohol-induced changes in antioxidant defenses in mice liver,” Toxicology Mechanisms and Methods, vol. 20, no. 2, pp. 82–89, 2010. View at Publisher · View at Google Scholar · View at Scopus
58. G. D. Rushing and L. D. Britt, “Reperfusion injury after hemorrhage: a collective review,” Annals of Surgery, vol. 247, no. 6, pp. 929–937, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
59. G. Papia, J. Fan, A. Kapus et al., “Altered inhibitory κb alpha expression in LPS-stimulated alveolar macrophages following resuscitated hemorrhagic shock,” Shock, vol. 35, no. 2, pp. 171–177, 2011. View at Publisher · View at Google Scholar
60. R. Schreck, P. Rieber, and P. A. Baeuerle, “Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-κB transcription factor and HIV-1,” EMBO Journal, vol. 10, no. 8, pp. 2247–2258, 1991. View at Scopus
61. J. I. Lee and G. J. Burckart, “Nuclear factor kappa B: important transcription factor and therapeutic target,” Journal of Clinical Pharmacology, vol. 38, no. 11, pp. 981–993, 1998. View at Scopus
62. S. Hattori, Y. Hattori, N. Banba, K. Kasai, and S. I. Shimoda, “Pentamethyl-hydroxychromane, vitamin E derivative, inhibits induction of nitric oxide synthase by bacterial lipopolysaccharide,” Biochemistry and Molecular Biology International, vol. 35, no. 1, pp. 177–183, 1995. View at Scopus
63. J. G. Kiang, P. D. Bowman, X. Lu et al., “Geldanamycin inhibits hemorrhage-induced increases in caspase-3 activity: role of inducible nitric oxide synthase,” Journal of Applied Physiology, vol. 103, no. 3, pp. 1045–1055, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
64. J. G. Kiang, S. Krishnan, X. Lu, and Y. Li, “Inhibition of inducible nitric-oxide synthase protects human T cells from hypoxia-induced apoptosis,” Molecular Pharmacology, vol. 73, no. 3, pp. 738–747, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
65. S. E. McKim, E. Gäbele, F. Isayama et al., “Inducible nitric oxide synthase is required in alcohol-induced liver injury: studies with knockout mice,” Gastroenterology, vol. 125, no. 6, pp. 1834–1844, 2003. View at Publisher · View at Google Scholar · View at Scopus
66. C. Hierholzer, B. Harbrecht, J. M. Menezes et al., “Essential role of induced nitric oxide in the initiation of the inflammatory response after hemorrhagic shock,” Journal of Experimental Medicine, vol. 187, no. 6, pp. 917–928, 1998. View at Publisher · View at Google Scholar · View at Scopus
67. E. C. Ayuste, H. Chen, E. Koustova et al., “Hepatic and pulmonary apoptosis after hemorrhagic shock in swine can be reduced through modifications of conventional Ringer's solution,” The Journal of trauma., vol. 60, no. 1, pp. 52–63, 2006. View at Scopus
68. R. Yang, M. H. Lisa, C. Woodall et al., “Administration of glutamine after hemorrhagic shock restores cellular energy, reduces cell apoptosis and damage, and increases survival,” Journal of Parenteral and Enteral Nutrition, vol. 31, no. 2, pp. 94–100, 2007. View at Publisher · View at Google Scholar · View at Scopus
69. S. R. Maitra, S. Bhaduri, R. El-Maghrabi, and M. J. Shapiro, “Inhibition of matrix metalloproteinase on hepatic transforming growth factor β1 and caspase-3 activation in hemorrhage,” Academic Emergency Medicine, vol. 12, no. 9, pp. 797–803, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
70. A. Benedetti, E. Brunelli, R. Risicato, T. Cilluffo, A. M. Jezequel, and F. Orlandi, “Subcellular changes and apoptosis induced by ethanol in rat liver,” Journal of Hepatology, vol. 6, no. 2, pp. 137–143, 1988. View at Scopus
71. P. R. Galle, W. J. Hofmann, H. Walczak et al., “Involvement of the CD95 (APO-1/Fas) receptor and ligand in liver damage,” Journal of Experimental Medicine, vol. 182, no. 5, pp. 1223–1230, 1995. View at Publisher · View at Google Scholar · View at Scopus
72. I. Kurose, H. Higuchi, S. Miura et al., “Oxidative stress-mediated apoptosis of hepatocytes exposed to acute ethanol intoxication,” Hepatology, vol. 25, no. 2, pp. 368–378, 1997. View at Scopus
73. A. M. Miller, N. Horiguchi, W. -I. Jeong, S. Radaeva, and B. Gao, “Molecular mechanisms of alcoholic liver disease: innate immunity and cytokines,” Alcoholism: Clinical and Experimental Research, vol. 35, no. 5, pp. 787–793, 2011. View at Publisher · View at Google Scholar · View at PubMed
74. F. Castañeda and R. K. H. Kinne, “Apoptosis induced in HepG2 cells by short exposure to millimolar concentrations of ethanol involves the Fas-receptor pathway,” Journal of Cancer Research and Clinical Oncology, vol. 127, no. 7, pp. 418–424, 2001. View at Publisher · View at Google Scholar · View at Scopus
75. S. L. Schendel, M. Montal, and J. C. Reed, “Bcl-2 family proteins as ion-channels,” Cell Death and Differentiation, vol. 5, no. 5, pp. 372–380, 1998. View at Scopus
76. A. Gross, J. M. McDonnell, and S. J. Korsmeyer, “BCL-2 family members and the mitochondria in apoptosis,” Genes and Development, vol. 13, no. 15, pp. 1899–1911, 1999. View at Scopus
77. J. C. Duvigneau, A. V. Kozlov, C. Zifko et al., “Reperfusion does not induce oxidative stress but sustained endoplasmic reticulum stress in livers of rats subjected to traumatic-hemorrhagic shock,” Shock, vol. 33, no. 3, pp. 289–298, 2010. View at Publisher · View at Google Scholar · View at Scopus