Therapeutic Approaches to Limit Hemolysis-Driven Endothelial Dysfunction:  Scavenging Free Heme to Preserve Vasculature Homeostasis

<table>Hemolysis-driven endothelial toxicity. Free Hb/heme is responsible for reduced NO availability and ROS generation that contribute to endothelial dysfunction leading to vasoconstriction, hypertension, and vasoocclusion. See text for details.</table>

Oxidative Medicine and Cellular Longevity

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Figure 1

Figure 1: Therapeutic Approaches to Limit Hemolysis-Driven Endothelial Dysfunction:  Scavenging Free Heme to Preserve Vasculature Homeostasis 