Frequency of Positive Surgical Margin at Prostatectomy and Its Effect on Patient Outcome

Table 3

The effect of margin status on PSA failure rate at 10 years.

First author, yr	𝑛	Cohort years	PSA fail criterion, ng/mL	% PSM, overall	% biochemical failure rate
					PSM	NSM	𝑃 value, HR
Williams 2011 [25]	158^††	2005–2009	—	13	No f/u
Ahyai 2010 [26]	932	1992–2004	≥0.1	12.9	21.7	6.9	𝑃=.001
Tsao 2009 [27]	100*	2004–2007	≥0.2	23	—
Sæther 2008 [28]	219	1996–2004	≥0.2	32.4	40	18	𝑃=.017
Pfitzenmaier 2008 [29]	406	1990–2006	≥0.2	17.2	64.3	20.5	𝑃<.001, HR 3.21
Swanson 2007 [30]	719	1985–1995	≥0.3	15.3	63	27	𝑃<.0001
Ahyai 2010 [26]	936	1992–2003	≥0.4	37	19	7	𝑃<.01
Kausik 2002 [31]	1202^†	1987–1995	>0.2	42	35	24	𝑃=.0001
Menon 2010 [32]	1384	2001–2005*	≥0.2	25.1	—	—	𝑃<.0001, HR 2.43 (1.72–3.42)

*Robotic only.
^†pT3 cases only.
^††pT2 cases only.