Frequency of Positive Surgical Margin at Prostatectomy and Its Effect on Patient Outcome

Table 6

Modification of prostate cancer mortality rates according to stage or grade, at 10 years.

First author, yr	𝑛	PSA Fail criterion, ng/mL	PSM, %	Median f/u, yr	PCa death rate if			PSM rate or HR by stage		PSM rate by grade
					PSM, %	NSM, %	𝑃 value, HR	pT2	pT3 a-b	Gleason ≥7	𝑃 value
Wright; 2010 [45]	65,633	—	21.2	7	0.86	0.33	𝑃<.001	17.7%	43.8%, 𝑃<.001	27.5% versus 18.3%	𝑃<.001
Boorjian 2010 [34]	11,729	≥0.4	31.1	8.2	4	1	𝑃=.15	HR 1.0	HR 2.1, 𝑃<.0001	—	—
Ploussard 2010 [34]	1943	>0.2	25.6	6.7	2.6	0.6	𝑃=.006, 3.7 (1.5–9.5)	16.0	33.6–40.2	—	—