Pseudolumen Size and Perimeter in Prostate Cancer: Correlation with Patient Outcome

Table 1

Pseudolumen measurements according to pattern, other than cribriform.

Histologic pattern	Nonfailures	Failures	Median for nonfailure	Median for failure	P value, Wilcoxon Rank Sum	Odds ratio, adjusted*	P value for odds ratio
Single separate acini	𝑛=80	𝑛=68
No. of pseudolumen spaces			39.5	42.9	.49	0.997	.79
Size of spaces based on mean, μm^2			160	130	.03	0.998	.16
Perimeter of spaces, μm			233	204	.004	0.996	.09
Perimeter/size ratio			1.49	1.58	.17	1.29	.49
Undulating-lumen separate acini	𝑛=61	𝑛=50
No. of pseudolumen spaces			34.0	30.5	.23	0.971	.06
Size of spaces based on mean, μm^2			342.9	314.5	.77	1.001	.03
Perimeter of spaces, μm			363	416	.69	1.002	.04
Perimeter/size ratio			1.19	1.21	.89	0.576	.39
Fused small acini:	𝑛=62	𝑛=62
No. of pseudolumen spaces			47.5	46.5	.75	0.975	.98
Size of spaces based on mean, μm^2			66.5	49.1	.002	0.066	.07
Perimeter of spaces, μm			147	117	.002	0.153	.15
Perimeter/size ratio			2.21	2.46	.003	0.059	.06
True papillary acini	𝑛=31	𝑛=43
No. of pseudolumen spaces			28.0	43.0	.008	1.05	.015
Size of spaces based on mean, μm^2			355.7	190.8	.025	0.99	.11
Perimeter of spaces, μm			382	262	.023	0.997	.04
Perimeter/size ratio			1.16	1.46	.061	4.77	.02

*By multivariate analysis adjusting for preoperative serum PSA, pathologic stage, grade, margin status, and the presence of the individual cell pattern.