Mouse Models of Prostate Cancer

Table 2

Prostate cancer transgenic mouse models.

Model	Year	Other tissues affected	Highest stage of neoplasia	Castration resistance	References
Mt-PRL	1997	Liver, thymus, kidney, pancreas, seminal vesicles, testes	Benign hyperplasia	No	[121–123]
BK5-IGF1	2000	Basal epithelial cells	Adenocarcinoma	No	[124, 125]
PB-mAR	2001	None	HGPIN	Not determined	[127]
ARR2PB-myc	2003	None	Adenocarcinoma	Partial	[132]
ARR2PB-FGFR1 (JOCK1)	2003	None	Hyperplasia	No	[134]
PB-Ras	2004	None	PIN	No	[136]
PB-neu	2006	None	Adenocarcinoma	Yes	[141]
ARR2PB-ERG	2008	None	PIN	Not determined	[142–145]
ARR2PB-hepsin/ ARR2PB-myc	2010	None	Adenocarcinoma	Partial	[133]