New Insights into the Androgen-Targeted Therapies and Epigenetic Therapies in Prostate Cancer

Table 2

List of HDACs that play a role in AR signaling.

Enzymes	Substrates	Modulation of AR signaling	References
HDAC1	Histones, p53, Smad7, Stat3, and so forth	Facilitates AR-dependent transcription; mechanism not fully clarified	[90, 94]
HDAC3	Histones, Smad7, Stat3, SRY, NFκB, and so forth	Facilitates AR-dependent transcription; mechanism not fully clarified	[90, 94]
HDAC6	Alpha-tubulin, HSP90	Deacetylates HSP90 which enhances chaperoning of AR protein	[9, 10, 93]