Table 2: List of HDACs that play a role in AR signaling.

EnzymesSubstratesModulation of AR signalingReferences

HDAC1Histones, p53, Smad7, Stat3, and so forthFacilitates AR-dependent transcription; mechanism not fully clarified[90, 94]
HDAC3Histones, Smad7, Stat3, SRY, NFκB, and so forthFacilitates AR-dependent transcription; mechanism not fully clarified[90, 94]
HDAC6Alpha-tubulin, HSP90Deacetylates HSP90 which enhances chaperoning of AR protein[9, 10, 93]