Table 2: List of HDACs that play a role in AR signaling.

Enzymes Substrates Modulation of AR signaling References HDAC1 Histones, p53, Smad7, Stat3, and so forth Facilitates AR-dependent transcription; mechanism not fully clarified [90, 94] HDAC3 Histones, Smad7, Stat3, SRY, NFκB, and so forth Facilitates AR-dependent transcription; mechanism not fully clarified [90, 94] HDAC6 Alpha-tubulin, HSP90 Deacetylates HSP90 which enhances chaperoning of AR protein [9, 10, 93]