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Prostate Cancer
Volume 2012 (2012), Article ID 302894, 12 pages
http://dx.doi.org/10.1155/2012/302894
Review Article

Markers of Field Cancerization: Proposed Clinical Applications in Prostate Biopsies

1Department of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
2New Mexico Cancer Center, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA

Received 6 February 2012; Accepted 8 March 2012

Academic Editor: Sandra M. Gaston

Copyright © 2012 Kristina A. Trujillo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Field cancerization denotes the occurrence of genetic, epigenetic, and biochemical aberrations in structurally intact cells in histologically normal tissues adjacent to cancerous lesions. This paper tabulates markers of prostate field cancerization known to date and discusses their potential clinical value in the analysis of prostate biopsies, including diagnosis, monitoring progression during active surveillance, and assessing efficacy of presurgical neoadjuvant and focal therapeutic interventions.