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Prostate Cancer
Volume 2012 (2012), Article ID 327253, 11 pages
http://dx.doi.org/10.1155/2012/327253
Review Article

Castration-Resistant Prostate Cancer: Mechanisms, Targets, and Treatment

Oncology Division, Hospital de Santa Maria, Instituto de Medicina Molecular, 1649-039 Lisbon, Portugal

Received 26 September 2011; Revised 1 December 2011; Accepted 20 December 2011

Academic Editor: William L. Dahut

Copyright © 2012 Teresa Maria Santos Amaral et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [17 citations]

The following is the list of published articles that have cited the current article.

  • Amit Bahl, “Metastatic castration-resistant prostate cancer. Part 1: the challenges of the disease and its treatment,” European Journal of Oncology Nursing, vol. 17, pp. S1–S6, 2013. View at Publisher · View at Google Scholar
  • Sébastien Fortin, Kevin Brasseur, Nathalie Morin, Éric Asselin, and Gervais Bérubé, “New platinum(II) complexes conjugate at position 7α of 17β-acetyl-testosterone as new combi-molecules against prostate cancer: Design, synthesis, structure-activity relationships and biological evaluation,” European Journal of Medicinal Chemistry, 2013. View at Publisher · View at Google Scholar
  • Thippeswamy Gulappa, Ramadevi Subramani Reddy, Suman Suman, Alice M. Nyakeriga, and Chendil Damodaran, “Molecular interplay between cdk4 and p21 dictates G0/G1 cell cycle arrest in prostate cancer cells,” Cancer Letters, 2013. View at Publisher · View at Google Scholar
  • Sausan Abouharb, and Paul G. Corn, “Optimal Therapy Sequencing in Metastatic Castration-Resistant Prostate Cancer,” Current Oncology Reports, vol. 15, no. 3, pp. 217–223, 2013. View at Publisher · View at Google Scholar
  • K. Franke, M. Baur, L. Daum, M. Vaegler, K.-D. Sievert, and B. Schlosshauer, “Prostate carcinoma cell growth-inhibiting hydrogel supports axonal regeneration in vitro,” Neuroscience Letters, vol. 541, pp. 248–252, 2013. View at Publisher · View at Google Scholar
  • Minyi He, Yun Liu, Xinjun Deng, Songtao Qi, Xuegang Sun, Gang Liu, Yongguang Liu, Yawei Liu, and Ming Zhao, “Down-regulation of miR-200b-3p by low p73 contributes to the androgen-independence of prostate cancer cells,” The Prostate, 2013. View at Publisher · View at Google Scholar
  • Zaki Shaikhibrahim, Roopika Menon, Martin Braun, Anne Offermann, Angela Queisser, Diana Boehm, Wenzel Vogel, Kerstin Rüenauver, Christian Ruiz, Tobias Zellweger, Maria Svensson, Ove Andren, Glen Kristiansen, Nicolas Wernert, Lukas Bubendorf, Jutta Kirfel, Saskia Biskup, and Sven Perner, “ MED15 , encoding a subunit of the mediator complex, is overexpressed at high frequency in castration-resistant prostate cancer ,” International Journal of Cancer, 2013. View at Publisher · View at Google Scholar
  • Roopika Menon, Mario Deng, Kerstin Rüenauver, Angela Queisser, Martin Pfeifer, Anne Offermann, Diana Boehm, Wenzel Vogel, Veit Scheble, Falko Fend, Glen Kristiansen, Nicolas Wernert, Nicole Oberbeckmann, Saskia Biskup, Mark A Rubin, Zaki Shaikhibrahim, and Sven Perner, “ Somatic copy number alterations by whole-exome sequencing implicates YWHAZ and PTK2 in castration-resistant prostate cancer ,” The Journal of Pathology, vol. 231, no. 4, pp. 505–516, 2013. View at Publisher · View at Google Scholar
  • Kimberley Carter, “Advances in prostate cancer treatment,” Nature Reviews Drug Discovery, vol. 12, no. 11, pp. 823–824, 2013. View at Publisher · View at Google Scholar
  • Sara Pignatta, Chiara Arienti, Wainer Zoli, Marzia Di Donato, Gabriella Castoria, Elisa Gabucci, Valentina Casadio, Mirella Falconi, Ugo De Giorgi, Rosella Silvestrini, and Anna Tesei, “Prolonged exposure to (R)-bicalutamide generates a LNCaP subclone with alteration of mitochondrial genome,” Molecular and Cellular Endocrinology, 2013. View at Publisher · View at Google Scholar
  • Archana Mukhopadhyay, Kayann Tabanor, Rathnam Chaguturu, and Jane V Aldrich, “Targeting inhibitor 2 of protein phosphatase 2A as a therapeutic strategy for prostate cancer treatment,” Cancer Biology & Therapy, vol. 14, no. 10, 2013. View at Publisher · View at Google Scholar
  • Tanya I. Stoyanova, and Andrew S. Goldstein, “Identification, characterization and targeting of Docetaxel-resistant prost ate cancer cells,” Asian Journal of Andrology, vol. 15, no. 1, pp. 83–84, 2013. View at Publisher · View at Google Scholar
  • Guillaume Ploussard, and Pierre Mongiat-Artus, “Triptorelin in the management of prostate cancer,” Future Oncology, vol. 9, no. 1, pp. 93–102, 2013. View at Publisher · View at Google Scholar
  • S. Belikov, C. Öberg, T. Jääskeläinen, V. Rahkama, J.J. Palvimo, and Ö. Wrange, “FoxA1 corrupts the antiandrogenic effect of bicalutamide but only weakly attenuates the effect of MDV3100 (Enzalutamide™),” Molecular and Cellular Endocrinology, vol. 365, no. 1, pp. 95–107, 2013. View at Publisher · View at Google Scholar
  • Sonia Liberati, Maria Beatrice Morelli, Massimo Nabissi, and Matteo Santoni, “Oncogenic and Anti-Oncogenic Effects of Transient Receptor Potential Channe ls,” Current Topics In Medicinal Chemistry, vol. 13, no. 3, pp. 344–366, 2013. View at Publisher · View at Google Scholar
  • James M. Jamison, Deborah Neal, and Jack L. Summers, “Synergistic Antitumor Cytotoxic Actions of Ascorbate and Menadione on Human Prostate (DU145) Cancer Cells In Vitro: Nucleus and Other Injuries Precedi ng Cell Death by Autoschizis,” Ultrastructural Pathology, vol. 38, no. 2, pp. 116–140, 2014. View at Publisher · View at Google Scholar
  • Matt Shirley, and Paul L. McCormack, “Radium-223 Dichloride: A Review of Its Use in Patients with Castration-Resistant Prostate Cancer with Symptomatic Bone Metastases,” Drugs, 2014. View at Publisher · View at Google Scholar